SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 9 GLY A  13
ASP A  37
ILE A  38
ALA A  88
ILE A 110
 None
 0.90A 1cetA-4e6pA:
10.5		 1cetA-4e6pA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 GLY A  13
ILE A  38
ASP A  39
ASP A  60
ILE A 110
 None
 0.62A 1qaoA-4e6pA:
5.5		 1qaoA-4e6pA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.82A 1wmqA-4e6pA:
undetectable		 1wmqA-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.83A 1wmqB-4e6pA:
undetectable		 1wmqB-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.80A 1wpuA-4e6pA:
undetectable		 1wpuA-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.81A 1wpuB-4e6pA:
undetectable		 1wpuB-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.84A 1wrqA-4e6pA:
undetectable		 1wrqA-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.86A 1wrqB-4e6pA:
undetectable		 1wrqB-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 GLY A  13
ASP A  37
ASP A  60
ASN A  87
ALA A  88
 None
 0.98A 2bm9E-4e6pA:
5.5		 2bm9E-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 GLU A   5
GLY A  30
ARG A  28
ALA A  31
ALA A   9
 None
 1.23A 2br4B-4e6pA:
5.0		 2br4B-4e6pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ILE A  18
ARG A  16
ARG A  42
ILE A  35
 None
 1.17A 2q72A-4e6pA:
undetectable		 2q72A-4e6pA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 11 GLY A  13
ILE A  38
ASP A  39
ASP A  60
ILE A 110
 None
 0.56A 3grvA-4e6pA:
6.6		 3grvA-4e6pA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 6 ILE A  18
ALA A 225
THR A 229
ALA A  25
 None
 0.90A 3mdrB-4e6pA:
undetectable		 3mdrB-4e6pA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 ALA A  46
ARG A  42
GLU A 226
ALA A 225
GLY A  17
 None
 1.00A 4r29B-4e6pA:
undetectable		 4r29B-4e6pA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 9 ALA A  23
ALA A  15
GLY A  19
ALA A  36
GLY A  13
 None
 1.06A 6bklE-4e6pA:
undetectable
6bklF-4e6pA:
undetectable
6bklG-4e6pA:
undetectable
6bklH-4e6pA:
undetectable		 6bklE-4e6pA:
8.37
6bklF-4e6pA:
8.37
6bklG-4e6pA:
8.37
6bklH-4e6pA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 GLY A  13
ASP A  37
ILE A  38
ASP A  39
ASP A  60
 None
 0.70A 6bq4A-4e6pA:
6.5		 6bq4A-4e6pA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		5 / 12 GLY A  13
ASP A  37
ILE A  38
ASP A  39
ASP A  60
 None
 0.66A 6bq4B-4e6pA:
6.4		 6bq4B-4e6pA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)
(Sinorhizobium
meliloti) 		4 / 4 VAL A 217
GLY A 252
ASP A 251
ASP A 227
 None
 1.32A 6cjkC-4e6pA:
undetectable		 6cjkC-4e6pA:
20.66