SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 12 ALA A 339
LEU A  46
GLY A 328
LEU A 362
GLN A 361
 None
None
APB  A 400 (-3.8A)
None
None
 0.93A 1qabF-4e6wA:
undetectable		 1qabF-4e6wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 5 LEU A 171
SER A 148
LEU A 194
LEU A 158
 None
 1.16A 1yajD-4e6wA:
undetectable		 1yajD-4e6wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 6 SER A 185
SER A 148
LEU A 150
GLY A 149
 None
 1.02A 2j2pA-4e6wA:
undetectable
2j2pC-4e6wA:
undetectable		 2j2pA-4e6wA:
21.67
2j2pC-4e6wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 6 SER A 185
SER A 148
LEU A 150
GLY A 149
 None
 1.03A 2j2pD-4e6wA:
undetectable
2j2pF-4e6wA:
undetectable		 2j2pD-4e6wA:
21.67
2j2pF-4e6wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 12 GLN A  70
PHE A  72
ARG A  50
ILE A  47
SER A  44
 None
 1.47A 2vdyA-4e6wA:
undetectable		 2vdyA-4e6wA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 5 ALA A 260
PRO A 259
TYR A 262
ALA A 254
 None
 1.25A 3twpD-4e6wA:
undetectable		 3twpD-4e6wA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		3 / 3 SER A 148
PHE A 184
LYS A 183
 None
PO4  A 401 (-3.6A)
None
 0.80A 3u88A-4e6wA:
undetectable		 3u88A-4e6wA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 7 ILE A 120
SER A 313
LEU A 114
VAL A 105
 None
 0.88A 3ua5B-4e6wA:
undetectable		 3ua5B-4e6wA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 9 ALA A 179
GLY A 149
LEU A 138
LEU A 150
ASN A 190
 None
 1.46A 3wdmA-4e6wA:
undetectable		 3wdmA-4e6wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 11 GLN A  70
PHE A  72
ARG A  50
ILE A  47
SER A  44
 None
 1.36A 4bb2A-4e6wA:
undetectable
4bb2B-4e6wA:
undetectable		 4bb2A-4e6wA:
22.25
4bb2B-4e6wA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 6 LEU A 176
LEU A 138
ILE A 120
MET A 127
 None
 0.89A 4do3B-4e6wA:
undetectable		 4do3B-4e6wA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 12 LEU A 340
ARG A 341
HIS A 279
LEU A 370
GLY A  67
 None
 1.24A 4l9qA-4e6wA:
undetectable		 4l9qA-4e6wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 6 SER A 313
GLN A 106
VAL A 140
THR A 139
 None
 1.39A 4lnxA-4e6wA:
undetectable		 4lnxA-4e6wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 7 GLN A 170
THR A 154
LEU A 150
THR A 139
 None
 1.07A 4mbsA-4e6wA:
undetectable		 4mbsA-4e6wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 5 HIS A 264
VAL A  90
GLU A  92
VAL A 226
 None
 1.36A 4p6vB-4e6wA:
undetectable
4p6vE-4e6wA:
undetectable		 4p6vB-4e6wA:
22.89
4p6vE-4e6wA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 4 VAL A 258
ALA A 260
PHE A 206
THR A 101
 None
 1.47A 4z4fA-4e6wA:
undetectable		 4z4fA-4e6wA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 4 VAL A 258
ALA A 260
PHE A 206
THR A 101
 None
 1.47A 4z4hA-4e6wA:
undetectable		 4z4hA-4e6wA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 8 THR A 147
ASP A 192
VAL A 105
GLY A 102
 None
 0.94A 5nzyA-4e6wA:
undetectable		 5nzyA-4e6wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		4 / 6 ARG A 341
ILE A 372
ASN A 368
ASP A 367
 None
 1.39A 6dhbA-4e6wA:
undetectable		 6dhbA-4e6wA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 12 GLU A 199
ILE A 198
GLY A 195
ALA A 166
VAL A 104
 None
 1.04A 6iftA-4e6wA:
undetectable		 6iftA-4e6wA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4e6w CLBP PEPTIDASE
(Escherichia
coli) 		5 / 12 PHE A 143
GLY A 314
ASP A 119
ILE A 120
ASN A 298
 None
 1.00A 6mhtA-4e6wA:
undetectable		 6mhtA-4e6wA:
23.24