SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 11 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.04A 2q6hA-4e77A:
undetectable		 2q6hA-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 11 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.01A 2q72A-4e77A:
undetectable		 2q72A-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.02A 2qb4A-4e77A:
undetectable		 2qb4A-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 11 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.03A 2qeiA-4e77A:
undetectable		 2qeiA-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 11 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.07A 2qjuA-4e77A:
undetectable		 2qjuA-4e77A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 LEU A 286
ALA A  96
VAL A  99
GLY A 277
THR A 297
 None
 1.14A 3c6gB-4e77A:
undetectable		 3c6gB-4e77A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.00A 3gwwA-4e77A:
undetectable		 3gwwA-4e77A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		3 / 3 SER A 114
GLY A 115
THR A 116
 NO3  A 502 (-4.7A)
NO3  A 502 (-3.5A)
None
 0.04A 3k9wA-4e77A:
undetectable		 3k9wA-4e77A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 9 VAL A 273
ILE A 267
ALA A 310
THR A 313
VAL A  99
 None
 1.27A 3me6D-4e77A:
undetectable		 3me6D-4e77A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		4 / 4 PHE A 402
TYR A 392
ILE A  71
LEU A  64
 None
 1.41A 3sudA-4e77A:
undetectable		 3sudA-4e77A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		3 / 3 ARG A 127
ARG A 124
ILE A 135
 None
 0.89A 4b7qA-4e77A:
undetectable		 4b7qA-4e77A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		3 / 3 ARG A 127
ARG A 124
ILE A 135
 None
 0.85A 4b7qC-4e77A:
undetectable		 4b7qC-4e77A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 11 SER A 114
THR A 119
SER A 121
TYR A 142
GLY A 144
 NO3  A 502 (-4.7A)
None
None
None
None
 1.41A 4qb9F-4e77A:
undetectable		 4qb9F-4e77A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 ALA A 285
ASP A 259
GLN A 251
GLY A 278
THR A 105
 None
 1.37A 5hfjH-4e77A:
undetectable		 5hfjH-4e77A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 ALA A 246
VAL A 245
GLU A 238
TYR A 253
ALA A 275
 None
 1.12A 5n5dA-4e77A:
2.3		 5n5dA-4e77A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		6 / 12 LEU A 247
ALA A 246
VAL A 245
GLU A 238
TYR A 253
ALA A 275
 None
 1.17A 5n5dB-4e77A:
undetectable		 5n5dB-4e77A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Yersinia
pestis) 		5 / 12 PHE A  26
LEU A   7
ILE A  15
LEU A 387
TYR A  52
 None
 1.44A 5ycpA-4e77A:
undetectable		 5ycpA-4e77A:
10.83