SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
None
0.62A 1etrH-4e7nA:
31.0
1etrH-4e7nA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
None
1.42A 2oxtA-4e7nA:
undetectable
2oxtA-4e7nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
None
1.41A 2oxtD-4e7nA:
undetectable
2oxtD-4e7nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 PHE A 173
ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
None
0.80A 2p16A-4e7nA:
11.5
2p16A-4e7nA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.34A 2pxcA-4e7nA:
undetectable
2pxcA-4e7nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 PHE A 173
ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
None
0.72A 2w26A-4e7nA:
10.6
2w26A-4e7nA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
None
0.61A 3gy3A-4e7nA:
12.8
3gy3A-4e7nA:
41.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.27A 3p97A-4e7nA:
undetectable
3p97A-4e7nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 3p97C-4e7nA:
undetectable
3p97C-4e7nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
4 / 7 ASP A 194
GLY A  44
THR A  45
THR A 190
None
1.05A 4ac9C-4e7nA:
undetectable
4ac9C-4e7nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 12 GLY A 142
ILE A 144
ILE A  16
SER A 195
ILE A 138
None
1.00A 4ax8A-4e7nA:
undetectable
4ax8A-4e7nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 12 GLY A 142
ILE A 144
ILE A  16
SER A 195
ILE A 138
None
0.97A 4azvA-4e7nA:
undetectable
4azvA-4e7nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 4ctjA-4e7nA:
undetectable
4ctjA-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.24A 4ctjC-4e7nA:
undetectable
4ctjC-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.28A 4ctkA-4e7nA:
undetectable
4ctkA-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.24A 4ctkC-4e7nA:
undetectable
4ctkC-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
4 / 7 GLY A  44
VAL A  31
PHE A 209
ILE A  47
None
0.79A 4fglC-4e7nA:
undetectable
4fglC-4e7nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
4 / 5 ASN A 161
LEU A 163
SER A 134
LEU A 181
None
1.22A 4n09C-4e7nA:
undetectable
4n09C-4e7nA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 12 GLY A  18
ILE A 185
GLY A 184
ARG A 137
ASN A 159
None
1.17A 4obwC-4e7nA:
undetectable
4obwC-4e7nA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
4 / 6 TRP A 237
ILE A 103
ILE A  66
VAL A  31
None
0.95A 4zj8A-4e7nA:
undetectable
4zj8A-4e7nA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.27A 5e9qA-4e7nA:
undetectable
5e9qA-4e7nA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 5e9qC-4e7nA:
undetectable
5e9qC-4e7nA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.29A 5ec8A-4e7nA:
undetectable
5ec8A-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.24A 5ec8C-4e7nA:
undetectable
5ec8C-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.27A 5ehgA-4e7nA:
undetectable
5ehgA-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 5ehgC-4e7nA:
undetectable
5ehgC-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.26A 5eifA-4e7nA:
undetectable
5eifA-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.24A 5eifC-4e7nA:
undetectable
5eifC-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.23A 5eiwC-4e7nA:
undetectable
5eiwC-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 5ekxB-4e7nA:
undetectable
5ekxB-4e7nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.30A 5ikmA-4e7nA:
undetectable
5ikmA-4e7nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
4 / 4 ASN A 161
LEU A 163
SER A 134
LEU A 181
None
1.17A 5kb5A-4e7nA:
undetectable
5kb5A-4e7nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.28A 5kqrA-4e7nA:
undetectable
5kqrA-4e7nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.28A 5kqsA-4e7nA:
undetectable
5kqsA-4e7nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 11 ALA A 227
VAL A 231
GLY A 197
GLY A 196
ASP A 102
None
0.89A 5lf7K-4e7nA:
undetectable
5lf7L-4e7nA:
undetectable
5lf7K-4e7nA:
22.51
5lf7L-4e7nA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
5 / 11 ALA A 227
VAL A 231
GLY A 197
GLY A 196
ASP A 102
None
0.89A 5lf7Y-4e7nA:
undetectable
5lf7Z-4e7nA:
undetectable
5lf7Y-4e7nA:
22.51
5lf7Z-4e7nA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.25A 5m5bA-4e7nA:
undetectable
5m5bA-4e7nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.27A 5njvA-4e7nA:
undetectable
5njvA-4e7nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.28A 5njvB-4e7nA:
undetectable
5njvB-4e7nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.34A 5wz2A-4e7nA:
undetectable
5wz2A-4e7nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius
halys)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
None
1.32A 5wz2B-4e7nA:
undetectable
5wz2B-4e7nA:
20.34