SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 ALA A 185
ILE A  81
PHE A 182
LEU A 150
LEU A 188
 None
 1.16A 1dtlA-4e7wA:
undetectable		 1dtlA-4e7wA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.31A 1hrkB-4e7wA:
undetectable		 1hrkB-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.32A 2hrcB-4e7wA:
undetectable		 2hrcB-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.36A 2pnjB-4e7wA:
undetectable		 2pnjB-4e7wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 8 ASP A 220
HIS A 154
SER A 149
LEU A 179
 None
 0.98A 2q0iA-4e7wA:
undetectable		 2q0iA-4e7wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.44A 2qd2A-4e7wA:
undetectable		 2qd2A-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		3 / 3 LEU A 337
PRO A 338
ARG A 325
 None
 0.63A 2qd5A-4e7wA:
undetectable		 2qd5A-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 6 ARG A 309
ILE A 198
ARG A 161
SER A 184
 None
PTR  A 197 ( 3.6A)
None
None
 1.42A 3ckzA-4e7wA:
undetectable		 3ckzA-4e7wA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 8 ALA A  64
LYS A  66
GLU A  78
LEU A 111
 None
 0.42A 3lfaA-4e7wA:
27.5		 3lfaA-4e7wA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 11 ARG A 161
HIS A 154
GLY A 157
GLY A 183
ASN A  76
 None
 1.49A 3v3nA-4e7wA:
undetectable		 3v3nA-4e7wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 11 ARG A 161
HIS A 154
GLY A 157
GLY A 183
ASN A  76
 None
 1.49A 3v3nD-4e7wA:
undetectable		 3v3nD-4e7wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 5 LYS A  66
ILE A  81
VAL A  91
ASP A 181
 None
 0.98A 3wzdA-4e7wA:
17.7		 3wzdA-4e7wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 ILE A 158
SER A 223
ILE A 163
ASN A 167
LEU A 179
 None
 0.90A 4gh8A-4e7wA:
undetectable		 4gh8A-4e7wA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 MET A 228
LEU A 231
GLY A 234
ILE A 298
PHE A 286
 None
 1.23A 4p6xA-4e7wA:
undetectable		 4p6xA-4e7wA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 MET A 228
LEU A 231
GLY A 234
ILE A 298
PHE A 286
 None
 1.20A 4udcA-4e7wA:
undetectable		 4udcA-4e7wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 7 ALA A 312
THR A 311
VAL A 350
HIS A 154
 None
 0.96A 5ecnA-4e7wA:
undetectable		 5ecnA-4e7wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 8 ILE A  44
GLY A  45
ASP A 181
PHE A 182
 None
 0.84A 5hieD-4e7wA:
20.4		 5hieD-4e7wA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 7 GLY A  45
GLY A  47
SER A  48
GLY A  50
VAL A  52
 None
 1.09A 5izjB-4e7wA:
24.8		 5izjB-4e7wA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 7 GLY A  45
GLY A  47
VAL A  52
LYS A  66
 None
 0.35A 5izjA-4e7wA:
24.8		 5izjA-4e7wA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 7 GLY A  45
GLY A  47
VAL A  52
LYS A  66
ASP A 181
 None
 0.55A 5j5xA-4e7wA:
24.4		 5j5xA-4e7wA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		7 / 12 ILE A  44
GLY A  45
VAL A  52
ALA A  64
LYS A  66
GLU A  78
LEU A 113
 None
 0.66A 5mafA-4e7wA:
23.9		 5mafA-4e7wA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 PHE A 320
ALA A 294
THR A 133
MET A 331
THR A 119
 None
 1.08A 5tl8A-4e7wA:
undetectable		 5tl8A-4e7wA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 12 MET A 143
LEU A 146
ILE A 298
LEU A 301
LEU A 231
 None
 1.12A 5toaB-4e7wA:
undetectable		 5toaB-4e7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 4 VAL A  52
LYS A  66
VAL A  91
ASN A 167
 None
 1.06A 5vc3A-4e7wA:
23.6		 5vc3A-4e7wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		5 / 10 ILE A 163
LEU A 150
LEU A 316
ALA A 315
LEU A 297
 None
 1.22A 5y7pG-4e7wA:
undetectable		 5y7pG-4e7wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4e7w GLYCOGEN SYNTHASE
KINASE 3
(Ustilago
maydis) 		4 / 8 GLY A 234
GLN A 233
SER A 124
TYR A 202
 None
 1.13A 6eqpA-4e7wA:
undetectable		 6eqpA-4e7wA:
12.50