SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 9 LEU A 169
LEU A 191
ILE A 193
LEU A 217
ILE A 215
 None
 1.21A 2f7aA-4e8bA:
undetectable		 2f7aA-4e8bA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 6 VAL A  64
ILE A   6
HIS A   8
ILE A  18
 None
 0.79A 3hegA-4e8bA:
undetectable		 3hegA-4e8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 7 ALA A 201
ILE A 204
ARG A 114
HIS A 172
 None
 0.95A 3v4tH-4e8bA:
undetectable		 3v4tH-4e8bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 12 PRO A 148
LEU A  82
ILE A 232
ALA A 228
ILE A 134
 None
 1.05A 3vrmA-4e8bA:
undetectable		 3vrmA-4e8bA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 8 SER A  76
ASP A 241
GLU A  75
THR A 233
 None
 0.98A 4lnwA-4e8bA:
undetectable		 4lnwA-4e8bA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 12 SER A 178
LEU A 222
THR A 227
THR A 230
ALA A 234
 None
 1.13A 5dsgB-4e8bA:
undetectable		 5dsgB-4e8bA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 12 THR A 227
LEU A 229
ALA A 228
ILE A 179
LEU A 171
 None
 1.19A 5gs4A-4e8bA:
undetectable		 5gs4A-4e8bA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 5 LEU A 110
PHE A 212
LEU A 199
TRP A 159
 None
 1.07A 5m10A-4e8bA:
undetectable		 5m10A-4e8bA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 4 GLU A 149
PRO A 148
ILE A 107
LEU A 106
 None
 1.36A 5m45D-4e8bA:
1.7		 5m45D-4e8bA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 6 GLY A 194
PRO A 195
GLU A 203
SER A 200
 None
 0.96A 5ny7A-4e8bA:
2.2		 5ny7A-4e8bA:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 11 LEU A 171
PRO A 173
LEU A 217
ARG A 223
THR A 224
 None
 1.14A 5o96A-4e8bA:
31.3
5o96B-4e8bA:
31.3		 5o96A-4e8bA:
48.39
5o96B-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 11 PRO A 173
LEU A 217
VAL A 221
ARG A 223
THR A 224
 None
 0.73A 5o96A-4e8bA:
31.3
5o96B-4e8bA:
31.3		 5o96A-4e8bA:
48.39
5o96B-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 9 ILE A 193
GLY A 194
GLY A 198
LEU A 217
LEU A 222
 None
 0.85A 5o96A-4e8bA:
31.3
5o96B-4e8bA:
31.3		 5o96A-4e8bA:
48.39
5o96B-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 10 LEU A 171
PRO A 173
GLY A 194
GLY A 198
LEU A 222
 None
 0.84A 5o96E-4e8bA:
25.5
5o96F-4e8bA:
31.4		 5o96E-4e8bA:
48.39
5o96F-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 10 LEU A 171
PRO A 173
VAL A 221
LEU A 222
ARG A 223
 None
 0.79A 5o96E-4e8bA:
25.5
5o96F-4e8bA:
31.4		 5o96E-4e8bA:
48.39
5o96F-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		6 / 11 LEU A 171
GLU A 196
LEU A 217
VAL A 221
ARG A 223
THR A 224
 None
 0.89A 5o96G-4e8bA:
31.7		 5o96G-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 10 LEU A 171
GLY A 194
GLY A 198
LEU A 217
LEU A 222
 None
 0.94A 5o96G-4e8bA:
31.7
5o96H-4e8bA:
30.9		 5o96G-4e8bA:
48.39
5o96H-4e8bA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		5 / 10 LEU A 171
LEU A 217
VAL A 221
LEU A 222
THR A 224
 None
 0.69A 5o96G-4e8bA:
31.7
5o96H-4e8bA:
30.9		 5o96G-4e8bA:
48.39
5o96H-4e8bA:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E
(Escherichia
coli) 		4 / 8 LEU A 167
VAL A 189
VAL A 186
ILE A 179
 None
 0.69A 5y9mX-4e8bA:
undetectable		 5y9mX-4e8bA:
17.57