SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 VAL A 322
LEU A 267
LEU A  41
LEU A  44
 None
 0.88A 1cqpA-4e8dA:
undetectable
1cqpB-4e8dA:
undetectable		 1cqpA-4e8dA:
15.91
1cqpB-4e8dA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 HIS A 278
SER A  37
HIS A  36
LYS A 341
 None
 1.32A 1eqbA-4e8dA:
undetectable
1eqbB-4e8dA:
undetectable		 1eqbA-4e8dA:
22.62
1eqbB-4e8dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 HIS A 278
SER A  37
HIS A  36
LYS A 341
 None
 1.32A 1eqbA-4e8dA:
undetectable
1eqbB-4e8dA:
undetectable		 1eqbA-4e8dA:
22.62
1eqbB-4e8dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 HIS A 278
SER A  37
HIS A  36
LYS A 341
 None
 1.32A 1eqbC-4e8dA:
undetectable
1eqbD-4e8dA:
undetectable		 1eqbC-4e8dA:
22.62
1eqbD-4e8dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 HIS A 278
SER A  37
HIS A  36
LYS A 341
 None
 1.32A 1eqbC-4e8dA:
undetectable
1eqbD-4e8dA:
undetectable		 1eqbC-4e8dA:
22.62
1eqbD-4e8dA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 VAL A 322
LEU A 259
ILE A 272
GLY A  22
LEU A 308
 None
 1.01A 1eqhA-4e8dA:
undetectable		 1eqhA-4e8dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 VAL A 322
LEU A 259
ILE A 272
GLY A  22
LEU A 308
 None
 1.00A 1eqhB-4e8dA:
undetectable		 1eqhB-4e8dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 4 GLY A 451
VAL A 453
TRP A  99
GLY A 102
 None
 0.96A 1ng8A-4e8dA:
undetectable		 1ng8A-4e8dA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 4 GLY A 451
VAL A 453
TRP A  99
GLY A 102
 None
 0.95A 1ng8B-4e8dA:
undetectable		 1ng8B-4e8dA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 5 ASP A 241
LEU A  44
ALA A 260
LEU A 259
 None
 1.14A 1nh8A-4e8dA:
undetectable		 1nh8A-4e8dA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 LEU A 364
GLY A 537
ILE A 495
LEU A 446
THR A 571
 None
 1.01A 1p91B-4e8dA:
undetectable		 1p91B-4e8dA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 SER A  21
ASN A  47
PHE A  46
ASN A 273
 None
 1.33A 1rs6B-4e8dA:
undetectable		 1rs6B-4e8dA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 SER A  21
ASN A  47
PHE A  46
ASN A 273
 None
 1.35A 1zzuA-4e8dA:
undetectable		 1zzuA-4e8dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 LEU A 104
ASN A  56
LEU A 108
ALA A 106
LEU A 460
 None
 1.25A 2aa6A-4e8dA:
undetectable		 2aa6A-4e8dA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 11 ARG A 402
ARG A 400
LYS A 420
VAL A 419
GLY A 504
 None
 1.46A 2h9tH-4e8dA:
undetectable		 2h9tH-4e8dA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		3 / 3 LYS A 436
ARG A 442
VAL A 414
 None
 1.04A 2r2vC-4e8dA:
undetectable
2r2vD-4e8dA:
undetectable		 2r2vC-4e8dA:
4.38
2r2vD-4e8dA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 ILE A  95
ASN A 454
GLY A 288
LEU A  57
TYR A  52
 None
 1.23A 2zw9A-4e8dA:
undetectable		 2zw9A-4e8dA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 6 ILE A 447
THR A 571
LYS A 530
PHE A 569
 None
 1.09A 3elzB-4e8dA:
undetectable		 3elzB-4e8dA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 TYR A 558
SER A 302
GLY A 280
ILE A 566
TYR A 522
 None
GOL  A 603 ( 4.0A)
None
None
None
 1.32A 3iizA-4e8dA:
9.9		 3iizA-4e8dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 GLU A 249
GLY A 242
GLU A  98
ALA A  97
GLY A 288
 None
 1.21A 3jzjA-4e8dA:
undetectable		 3jzjA-4e8dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 GLU A  50
TYR A 303
PHE A  27
ARG A  90
 None
 1.15A 3mjrD-4e8dA:
undetectable		 3mjrD-4e8dA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 TYR A 216
PRO A 215
GLN A 269
GLU A 265
 None
 1.01A 3oyaA-4e8dA:
undetectable		 3oyaA-4e8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 4 LYS A 436
GLN A 417
ILE A 431
LEU A 479
 None
 1.30A 3qt0A-4e8dA:
undetectable		 3qt0A-4e8dA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 TYR A 216
PRO A 215
GLN A 269
GLU A 265
 None
 0.93A 3s3mA-4e8dA:
undetectable		 3s3mA-4e8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 TYR A 216
PRO A 215
GLN A 269
GLU A 265
 None
 0.92A 3s3nA-4e8dA:
undetectable		 3s3nA-4e8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 TYR A 216
PRO A 215
GLN A 269
GLU A 265
 None
 0.94A 3s3oA-4e8dA:
undetectable		 3s3oA-4e8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 ILE A 579
LYS A 588
PHE A 543
GLY A 529
 None
 1.03A 3selX-4e8dA:
undetectable		 3selX-4e8dA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 ILE A 579
LYS A 588
PHE A 543
GLY A 529
 None
 1.06A 3sj0X-4e8dA:
undetectable		 3sj0X-4e8dA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 11 PHE A 459
HIS A 457
PHE A 101
GLY A 288
ASN A  56
 None
 1.29A 3v3nA-4e8dA:
undetectable		 3v3nA-4e8dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 11 PHE A 459
HIS A 457
PHE A 101
GLY A 288
ASN A  56
 None
 1.29A 3v3nD-4e8dA:
1.4		 3v3nD-4e8dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 GLN A 335
PHE A  46
ASN A  40
GLY A  45
GLU A 258
 None
 1.03A 3v3oB-4e8dA:
undetectable		 3v3oB-4e8dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 GLY A 208
ASP A 187
GLY A 188
VAL A 206
 None
 0.94A 4c5nA-4e8dA:
2.3		 4c5nA-4e8dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 GLY A 208
ASP A 187
GLY A 188
VAL A 206
 None
 0.88A 4c5nC-4e8dA:
2.0		 4c5nC-4e8dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		3 / 3 ARG A  28
HIS A  25
TYR A 303
 None
 1.26A 4fu8A-4e8dA:
undetectable		 4fu8A-4e8dA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 6 LEU A 274
MET A 326
LEU A  20
ILE A  88
 None
 1.00A 4okxA-4e8dA:
undetectable		 4okxA-4e8dA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 LEU A  41
LEU A  44
ALA A  43
GLY A  84
LEU A  83
 None
None
None
GOL  A 602 (-3.8A)
None
 1.08A 4pxmA-4e8dA:
undetectable		 4pxmA-4e8dA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 GLY A 208
GLU A 265
ALA A 262
GLY A 211
PHE A 210
 None
 1.21A 4r29B-4e8dA:
undetectable		 4r29B-4e8dA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		3 / 3 GLU A 238
TYR A 303
GLU A  98
 None
 0.84A 4ryaA-4e8dA:
undetectable		 4ryaA-4e8dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 6 GLU A  68
PHE A  67
PHE A  65
HIS A  66
 None
 1.49A 4uciA-4e8dA:
undetectable		 4uciA-4e8dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 5 LEU A 133
TYR A 129
ALA A  54
ILE A  95
 None
 1.17A 4y03B-4e8dA:
undetectable		 4y03B-4e8dA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 ILE A 272
PHE A  46
ARG A 264
LEU A 259
 None
 0.85A 5b1bN-4e8dA:
undetectable
5b1bW-4e8dA:
undetectable		 5b1bN-4e8dA:
20.66
5b1bW-4e8dA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 ILE A 272
PHE A  46
ARG A 264
LEU A 259
 None
 0.86A 5b3sN-4e8dA:
undetectable
5b3sW-4e8dA:
undetectable		 5b3sN-4e8dA:
20.66
5b3sW-4e8dA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 TYR A  52
CYH A  96
GLU A  98
GLU A 156
TYR A 275
 None
 0.68A 5gsmA-4e8dA:
29.0		 5gsmA-4e8dA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		5 / 12 TYR A  52
CYH A  96
GLU A  98
GLU A 238
TYR A 275
 None
 0.46A 5gsmA-4e8dA:
29.0		 5gsmA-4e8dA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		6 / 12 TYR A  52
CYH A  96
GLU A  98
GLU A 156
GLU A 238
TYR A 275
 None
 0.74A 5gsmB-4e8dA:
30.1		 5gsmB-4e8dA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 LEU A 460
TYR A 166
GLU A 154
SER A  92
 None
 1.16A 5umwA-4e8dA:
undetectable
5umwF-4e8dA:
undetectable		 5umwA-4e8dA:
8.75
5umwF-4e8dA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 6 PRO A 334
GLY A  45
TYR A 333
LEU A  85
 None
 0.95A 5x80A-4e8dA:
undetectable
5x80B-4e8dA:
undetectable		 5x80A-4e8dA:
14.45
5x80B-4e8dA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 7 VAL A 355
LEU A 412
PHE A 569
LEU A 446
 None
 1.16A 6aycA-4e8dA:
undetectable		 6aycA-4e8dA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4e8d GLYCOSYL HYDROLASE,
FAMILY 35
(Streptococcus
pneumoniae) 		4 / 8 TYR A 130
PHE A  67
HIS A  58
VAL A  53
 None
 1.22A 6huoC-4e8dA:
undetectable
6huoD-4e8dA:
undetectable		 6huoC-4e8dA:
9.08
6huoD-4e8dA:
9.57