SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		5 / 9 GLY A  41
THR A  45
HIS A  43
THR A  36
ILE A  34
 None
 1.20A 1gtfD-4e8eA:
undetectable
1gtfE-4e8eA:
undetectable		 1gtfD-4e8eA:
13.82
1gtfE-4e8eA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		3 / 3 ASP A  84
LYS A  90
ARG A  95
 None
 1.13A 1ra8A-4e8eA:
undetectable		 1ra8A-4e8eA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 5 LEU A 102
ASP A  99
VAL A 159
ILE A  98
 None
 0.97A 2aoiB-4e8eA:
undetectable		 2aoiB-4e8eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 8 LEU A  27
LEU A  77
ALA A  80
MET A  60
 None
 1.07A 2wekA-4e8eA:
undetectable		 2wekA-4e8eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 8 PHE A 104
THR A 163
ILE A 164
THR A 167
 None
 0.87A 3bpxA-4e8eA:
undetectable
3bpxB-4e8eA:
1.2		 3bpxA-4e8eA:
21.68
3bpxB-4e8eA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		5 / 12 LEU A   8
ALA A  72
THR A  75
VAL A 159
VAL A  20
 None
 0.90A 3rukA-4e8eA:
undetectable		 3rukA-4e8eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 7 THR A  23
ALA A  19
THR A 163
VAL A 159
 None
 0.94A 4ik7A-4e8eA:
undetectable		 4ik7A-4e8eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 8 SER A  70
GLN A  74
VAL A 166
THR A 167
 None
 0.89A 4lnwA-4e8eA:
undetectable		 4lnwA-4e8eA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 6 SER A  70
GLN A  74
VAL A 166
THR A 167
 None
 1.07A 4lnxA-4e8eA:
undetectable		 4lnxA-4e8eA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 6 ILE A 171
ILE A 184
PHE A 135
LEU A 109
 None
 0.96A 4m51A-4e8eA:
undetectable		 4m51A-4e8eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		5 / 12 PHE A 188
TYR A 110
LEU A 114
ILE A 171
TYR A 200
 None
 1.23A 5ifuA-4e8eA:
undetectable		 5ifuA-4e8eA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4e8e GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 5 VAL A 159
THR A  75
ASP A  99
LEU A 102
 None
 1.22A 5m0iB-4e8eA:
undetectable		 5m0iB-4e8eA:
22.18