SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		4 / 8 ARG A  18
TRP A  22
GLU A  79
ASP A 115
 None
None
None
CL  A 201 ( 3.9A)
 0.51A 1s3zA-4e8oA:
23.0
1s3zB-4e8oA:
23.0		 1s3zA-4e8oA:
46.43
1s3zB-4e8oA:
46.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVY_A_TOYA201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		6 / 9 ARG A  18
TRP A  22
GLU A  32
GLU A  79
GLY A  80
ASP A 115
 None
None
None
None
None
CL  A 201 ( 3.9A)
 0.37A 4evyA-4e8oA:
25.8
4evyB-4e8oA:
24.6		 4evyA-4e8oA:
74.25
4evyB-4e8oA:
74.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		6 / 10 ARG A  18
TRP A  22
ASP A  24
GLU A  79
GLY A  80
ASP A 115
 None
None
None
None
None
CL  A 201 ( 3.9A)
 0.55A 4evyA-4e8oA:
25.8
4evyB-4e8oA:
24.6		 4evyA-4e8oA:
74.25
4evyB-4e8oA:
74.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		6 / 10 ARG A  18
TRP A  22
GLU A  32
GLU A  79
GLY A  80
ASP A 115
 None
None
None
None
None
CL  A 201 ( 3.9A)
 0.41A 4evyA-4e8oA:
25.8
4evyB-4e8oA:
24.6		 4evyA-4e8oA:
74.25
4evyB-4e8oA:
74.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		5 / 12 GLY A 131
LEU A  58
LEU A  43
ARG A  42
ALA A  76
 None
 1.24A 4wcxC-4e8oA:
undetectable		 4wcxC-4e8oA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4e8o AAC(6')-IH PROTEIN
(Acinetobacter
baumannii) 		5 / 9 LEU A 130
GLY A 131
GLU A 101
VAL A  97
THR A  94
 None
 1.37A 4x3mA-4e8oA:
undetectable		 4x3mA-4e8oA:
19.77