SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 8 LEU A 648
VAL A 691
CYH A 689
GLY A 642
 None
None
None
GUI  A 901 (-3.5A)
 1.01A 1jlfA-4e93A:
undetectable
1jlfB-4e93A:
undetectable		 1jlfA-4e93A:
22.60
1jlfB-4e93A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
VAL A 575
ALA A 588
GLU A 607
LEU A 674
HIS A 681
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
 1.10A 1uwjB-4e93A:
28.7		 1uwjB-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
GLY A 642
LEU A 645
ARG A 649
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.83A 1xkkA-4e93A:
31.7		 1xkkA-4e93A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 LEU A 537
LEU A 481
SER A 494
LEU A 493
VAL A 492
 None
 1.22A 2c12C-4e93A:
undetectable		 2c12C-4e93A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 MET A 793
LEU A 750
LEU A 756
LEU A 660
ILE A 817
 None
 0.90A 2ouzA-4e93A:
undetectable		 2ouzA-4e93A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 SER A 494
VAL A 495
GLN A 535
THR A 533
HIS A 529
 None
 1.22A 2vdyA-4e93A:
undetectable		 2vdyA-4e93A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 8 LEU A 684
ILE A 619
TYR A 614
PHE A 702
 None
 0.95A 2weyB-4e93A:
undetectable		 2weyB-4e93A:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ILE A 567
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.82A 2y6oA-4e93A:
34.9		 2y6oA-4e93A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.73A 2y7jA-4e93A:
19.8		 2y7jA-4e93A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.57A 2y7jB-4e93A:
20.4		 2y7jB-4e93A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.59A 2y7jC-4e93A:
26.3		 2y7jC-4e93A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.55A 2y7jD-4e93A:
20.3		 2y7jD-4e93A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.63A 2zvaA-4e93A:
35.9		 2zvaA-4e93A:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ALA A 588
LYS A 590
VAL A 620
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.53A 3aoxA-4e93A:
32.9		 3aoxA-4e93A:
34.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LEU A 622
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.67A 3bbtB-4e93A:
31.2		 3bbtB-4e93A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.93A 3bbtB-4e93A:
31.2		 3bbtB-4e93A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.77A 3k54A-4e93A:
33.4		 3k54A-4e93A:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 9 PHE A 480
VAL A 495
VAL A 549
TRP A 460
GLY A 478
 None
 1.45A 3km6B-4e93A:
undetectable		 3km6B-4e93A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 10 VAL A 587
VAL A 589
GLY A 578
VAL A 562
GLY A 564
 None
 1.08A 3ls4H-4e93A:
undetectable		 3ls4H-4e93A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 LEU A 530
VAL A 482
VAL A 495
LEU A 526
PRO A 524
 None
 1.12A 3mecA-4e93A:
2.0		 3mecA-4e93A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 11 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
GUI  A 901 ( 4.1A)
 0.75A 3miyA-4e93A:
35.0		 3miyA-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 11 ILE A 567
ALA A 588
LYS A 590
VAL A 620
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.64A 3miyA-4e93A:
35.0		 3miyA-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 9 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.64A 3miyB-4e93A:
34.8		 3miyB-4e93A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
VAL A 575
ALA A 588
LYS A 590
LEU A 611
PHE A 702
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
 1.29A 3og7A-4e93A:
29.1		 3og7A-4e93A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.39A 3sxrA-4e93A:
33.6		 3sxrA-4e93A:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 9 ILE A 567
ALA A 588
VAL A 620
ASP A 643
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 0.41A 3ti1A-4e93A:
23.9		 3ti1A-4e93A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
GLY A 573
VAL A 575
ALA A 588
LYS A 590
ASP A 701
 GUI  A 901 (-4.0A)
None
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 ( 4.1A)
 0.79A 3v5wA-4e93A:
8.0		 3v5wA-4e93A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 5 ILE A 610
VAL A 620
LEU A 690
ASP A 701
 None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.80A 3wzdA-4e93A:
32.5		 3wzdA-4e93A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
LEU A 638
GLY A 642
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.59A 3zbfA-4e93A:
35.0		 3zbfA-4e93A:
35.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 SER A 494
VAL A 495
GLN A 535
THR A 533
HIS A 529
 None
 1.18A 4c49A-4e93A:
undetectable		 4c49A-4e93A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
ASP A 643
ASP A 683
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
None
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.71A 4i41A-4e93A:
24.1		 4i41A-4e93A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
ALA A 588
VAL A 620
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.50A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
ALA A 588
VAL A 620
MET A 636
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.53A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		9 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 638
GLY A 642
ASP A 643
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.46A 4mkcA-4e93A:
34.4		 4mkcA-4e93A:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.81A 4mxoB-4e93A:
35.5		 4mxoB-4e93A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4mxyA-4e93A:
28.4		 4mxyA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
GLU A 607
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
None
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.62A 4mxyA-4e93A:
28.4		 4mxyA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.51A 4mxyB-4e93A:
28.5		 4mxyB-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
GLU A 607
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
None
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.62A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.51A 4mxzB-4e93A:
28.5		 4mxzB-4e93A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 8 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.54A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 8 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.74A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 7 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4ogrE-4e93A:
26.1		 4ogrE-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 9 ILE A 567
ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.77A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 9 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.78A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.66A 4qmnA-4e93A:
21.6		 4qmnA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 11 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 4qmsA-4e93A:
21.6		 4qmsA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
MET A 636
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 0.81A 4qmzA-4e93A:
29.6		 4qmzA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 9 ILE A 817
PHE A 754
LEU A 661
LEU A 750
PHE A 746
 None
 1.41A 4qopB-4e93A:
undetectable		 4qopB-4e93A:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
GLU A 607
LEU A 674
CYH A 679
ARG A 682
 GUI  A 901 (-3.4A)
None
None
None
None
 1.08A 4qrcA-4e93A:
32.2		 4qrcA-4e93A:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 10 ILE A 567
ALA A 588
LEU A 638
VAL A 639
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-4.0A)
GUI  A 901 (-4.3A)
 0.68A 4rz7A-4e93A:
18.2		 4rz7A-4e93A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
LEU A 611
GLY A 642
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
 0.40A 4u0iA-4e93A:
32.8		 4u0iA-4e93A:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
LEU A 674
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
None
None
GUI  A 901 (-4.3A)
 0.37A 4uxqA-4e93A:
32.6		 4uxqA-4e93A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
GLU A 607
LEU A 674
CYH A 679
HIS A 681
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
None
 1.01A 4v04A-4e93A:
32.1		 4v04A-4e93A:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LYS A 590
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.72A 4xeyA-4e93A:
34.7		 4xeyA-4e93A:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
LYS A 590
LEU A 611
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 ( 4.1A)
None
 0.96A 4xv2B-4e93A:
29.5		 4xv2B-4e93A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 5 GLY A 570
ARG A 569
GLY A 568
GLU A 574
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.3A)
None
 1.27A 4z2eB-4e93A:
undetectable
4z2eC-4e93A:
undetectable		 4z2eB-4e93A:
21.98
4z2eC-4e93A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 11 PHE A 644
ALA A 686
LEU A 784
LEU A 655
LEU A 756
 None
 1.07A 4zmeA-4e93A:
5.3		 4zmeA-4e93A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 10 PHE A 644
ALA A 686
LEU A 784
LEU A 655
LEU A 756
 None
 1.07A 4zmeB-4e93A:
5.3		 4zmeB-4e93A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.75A 5h2uA-4e93A:
32.1		 5h2uA-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.90A 5h2uB-4e93A:
32.4		 5h2uB-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
ILE A 634
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.51A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
ALA A 588
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.58A 5i9xA-4e93A:
34.6		 5i9xA-4e93A:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
ALA A 588
LYS A 590
GLU A 607
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.59A 5i9yA-4e93A:
34.4		 5i9yA-4e93A:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.65A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.03A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.86A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
LYS A 590
GLU A 607
GLY A 642
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
 0.80A 5mafA-4e93A:
27.0		 5mafA-4e93A:
13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.3A)
 0.78A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.36A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.23A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.74A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		3 / 3 HIS A 681
SER A 700
ARG A 687
 None
GUI  A 901 (-3.1A)
None
 0.99A 5u63A-4e93A:
undetectable		 5u63A-4e93A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 4 VAL A 620
LEU A 638
ASN A 688
ASP A 701
 None
GUI  A 901 (-4.4A)
GUI  A 901 (-4.6A)
GUI  A 901 ( 4.1A)
 0.84A 5vcyA-4e93A:
25.0		 5vcyA-4e93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 1.01A 5yu9D-4e93A:
30.6		 5yu9D-4e93A:
13.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		9 / 12 ILE A 567
VAL A 575
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.76A 6fnmA-4e93A:
35.7		 6fnmA-4e93A:
32.48