SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 10 LEU A  31
ASN A 118
VAL A 116
GLY A 115
LEU A  29
 None
 1.27A 1fkoA-4e9kA:
undetectable		 1fkoA-4e9kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 7 LEU A 232
PHE A  76
PHE A 234
LEU A 223
 None
 1.05A 1wrlE-4e9kA:
undetectable
1wrlF-4e9kA:
undetectable		 1wrlE-4e9kA:
17.01
1wrlF-4e9kA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		3 / 3 GLY A  72
ASP A  69
SER A  30
 None
 0.63A 3brfA-4e9kA:
undetectable		 3brfA-4e9kA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 8 ASP A 145
TYR A  27
GLY A  72
ILE A  73
 None
 0.78A 3ihzB-4e9kA:
undetectable		 3ihzB-4e9kA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 8 PRO A 249
SER A 171
SER A 238
ASP A 189
 None
 1.10A 3lsfH-4e9kA:
undetectable		 3lsfH-4e9kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		5 / 12 LEU A  31
ASN A 118
VAL A 116
GLY A 115
LEU A  29
 None
 1.33A 3medA-4e9kA:
undetectable
3medB-4e9kA:
undetectable		 3medA-4e9kA:
16.73
3medB-4e9kA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 4 LEU A 160
ILE A 259
GLY A 256
PHE A  74
 None
 1.09A 4dc3A-4e9kA:
undetectable		 4dc3A-4e9kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		3 / 3 THR A 239
SER A 190
ASP A 205
 None
 0.52A 5kvaA-4e9kA:
undetectable		 5kvaA-4e9kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		3 / 3 THR A 239
SER A 190
ASP A 205
 None
 0.50A 5kvaB-4e9kA:
undetectable		 5kvaB-4e9kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 7 THR A  68
LEU A  67
VAL A  79
TYR A  64
 None
None
None
SO4  A 300 (-4.5A)
 0.88A 5ov9A-4e9kA:
undetectable		 5ov9A-4e9kA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 8 THR A  68
LEU A  67
VAL A  79
TYR A  64
 None
None
None
SO4  A 300 (-4.5A)
 0.90A 5ov9B-4e9kA:
undetectable		 5ov9B-4e9kA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4e9k HYPOTHETICAL PROTEIN
(Bacteroides
ovatus) 		4 / 4 LEU A 215
ASP A 216
GLN A 217
VAL A 157
 None
 1.49A 6bzoF-4e9kA:
undetectable		 6bzoF-4e9kA:
18.30