SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4e9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 11 HIS X  67
VAL X  94
TYR X 104
LEU X 114
TRP X 182
 IOD  X 309 (-4.6A)
IOD  X 310 ( 4.9A)
None
None
None
 0.81A 1dmyA-4e9oX:
33.0		 1dmyA-4e9oX:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 GLU X  90
ASN X  92
TRP X 182
 None
 1.18A 1r15C-4e9oX:
undetectable		 1r15C-4e9oX:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 GLU X  90
ASN X  92
TRP X 182
 None
 1.24A 1r15D-4e9oX:
undetectable		 1r15D-4e9oX:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 GLU X  90
ASN X  92
TRP X 182
 None
 1.20A 1r15E-4e9oX:
undetectable		 1r15E-4e9oX:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 GLU X  90
ASN X  92
TRP X 182
 None
 1.21A 1r15F-4e9oX:
undetectable		 1r15F-4e9oX:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 12 PHE X 185
ILE X 119
ILE X  91
HIS X  95
LEU X  63
 None
 1.23A 2ft9A-4e9oX:
1.8		 2ft9A-4e9oX:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 12 LEU X 170
VAL X 181
SER X   6
VAL X 231
LEU X  21
 None
 1.39A 2zlcA-4e9oX:
undetectable		 2zlcA-4e9oX:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 GLY X  89
GLY X  71
GLY X  77
 None
 0.44A 3bogC-4e9oX:
undetectable		 3bogC-4e9oX:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 12 GLY X  50
GLY X  49
LYS X  48
ASP X 112
GLY X 113
 IOD  X 306 ( 4.6A)
IOD  X 306 ( 4.4A)
None
None
None
 0.79A 4fp9D-4e9oX:
undetectable		 4fp9D-4e9oX:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 12 GLY X  50
GLY X  49
LYS X  48
ASP X 112
GLY X 113
 IOD  X 306 ( 4.6A)
IOD  X 306 ( 4.4A)
None
None
None
 0.82A 4fzvA-4e9oX:
undetectable		 4fzvA-4e9oX:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		5 / 12 LEU X  93
LEU X 159
ASN X 158
ILE X  45
ILE X 134
 None
None
IOD  X 301 (-4.6A)
None
None
 1.11A 4o2bB-4e9oX:
undetectable		 4o2bB-4e9oX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4e9o IMV MEMBRANE PROTEIN
(Vaccinia
virus) 		3 / 3 SER X 118
HIS X  80
TYR X 169
 None
 0.98A 5y2tA-4e9oX:
undetectable		 5y2tA-4e9oX:
undetectable