SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ea1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 167
ILE A 249
MET A 227
LEU A 164
ILE A 241
 None
None
None
3RX  A 301 ( 4.5A)
None
 1.12A 1bsxA-4ea1A:
undetectable		 1bsxA-4ea1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 167
ILE A 249
MET A 227
LEU A 164
ILE A 241
 None
None
None
3RX  A 301 ( 4.5A)
None
 1.12A 1bsxB-4ea1A:
undetectable		 1bsxB-4ea1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ARG A 158
VAL A 140
LEU A 141
ALA A 157
 None
 0.99A 2e1qC-4ea1A:
undetectable		 2e1qC-4ea1A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ALA A 219
ASP A 222
GLU A 220
ARG A 256
 None
 1.11A 2ouzA-4ea1A:
undetectable		 2ouzA-4ea1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 ARG A 158
VAL A 140
LEU A 141
ALA A 157
 None
 0.93A 3ax7A-4ea1A:
undetectable		 3ax7A-4ea1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 THR A 153
VAL A 156
ILE A 241
THR A 142
 None
 0.82A 3deuA-4ea1A:
undetectable		 3deuA-4ea1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 9 VAL A 173
LEU A 166
TYR A 214
LEU A 126
ASP A 123
 None
 1.23A 3hthB-4ea1A:
1.0		 3hthB-4ea1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		6 / 12 LEU A 126
VAL A 133
GLY A 132
LEU A 107
LEU A 166
ILE A 167
 None
3RX  A 301 (-4.2A)
None
3RX  A 301 ( 4.9A)
None
None
 1.47A 3ijdA-4ea1A:
undetectable		 3ijdA-4ea1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 LEU A 126
VAL A 133
LEU A 107
LEU A 166
ILE A 167
 None
3RX  A 301 (-4.2A)
3RX  A 301 ( 4.9A)
None
None
 1.16A 3ijdB-4ea1A:
undetectable		 3ijdB-4ea1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 11 ARG A  34
GLN A  33
LEU A 145
ALA A 245
PHE A  26
 None
 1.35A 3jwqA-4ea1A:
2.7
3jwqD-4ea1A:
3.0		 3jwqA-4ea1A:
19.76
3jwqD-4ea1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ILE A 249
MET A 227
LEU A 164
SER A 163
ILE A 241
 None
None
3RX  A 301 ( 4.5A)
None
None
 1.17A 4lnxA-4ea1A:
undetectable		 4lnxA-4ea1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 GLU A  71
ASP A  66
ILE A  67
ILE A 108
 None
 0.93A 4ndnD-4ea1A:
undetectable		 4ndnD-4ea1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PHE A  59
GLN A  58
ILE A  51
ASP A  52
 None
 0.93A 4pcuA-4ea1A:
undetectable		 4pcuA-4ea1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 ILE A  63
PHE A  59
VAL A  43
ILE A  86
 None
 0.98A 4zzbC-4ea1A:
4.7
4zzbD-4ea1A:
4.7		 4zzbC-4ea1A:
21.70
4zzbD-4ea1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ILE A  14
MET A   4
ASP A  83
 None
 0.66A 5h2uA-4ea1A:
undetectable		 5h2uA-4ea1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 CYH A  11
LYS A   9
HIS A  12
 None
 1.13A 5js5A-4ea1A:
2.9		 5js5A-4ea1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 GLU A  71
ASP A  66
ILE A  67
ILE A 108
 None
 0.89A 6fbnA-4ea1A:
undetectable		 6fbnA-4ea1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ea1 DEHYDROSQUALENE
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ILE A  47
ALA A  42
ARG A  45
MET A  15
 None
None
3RX  A 301 ( 3.9A)
None
 1.11A 6hu9m-4ea1A:
undetectable
6hu9q-4ea1A:
undetectable		 6hu9m-4ea1A:
19.46
6hu9q-4ea1A:
17.77