SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		4 / 5 ARG A 166
ALA A 147
ASP A 184
GLY A 164
 None
 1.12A 1e7bA-4eaaA:
undetectable		 1e7bA-4eaaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		4 / 5 ARG A 166
ALA A 148
ASP A 184
GLY A 164
 None
 1.02A 1e7bA-4eaaA:
undetectable		 1e7bA-4eaaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		5 / 12 VAL A  10
LEU A  61
ILE A  23
ILE A  36
VAL A  52
 None
 1.36A 3w67D-4eaaA:
undetectable		 3w67D-4eaaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		3 / 3 SER A 104
ALA A 120
VAL A 119
 None
 0.53A 4o2bA-4eaaA:
undetectable		 4o2bA-4eaaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		4 / 7 LEU A  66
ARG A  62
LEU A  61
LEU A   5
 None
 0.81A 4wg0L-4eaaA:
undetectable
4wg0M-4eaaA:
undetectable		 4wg0L-4eaaA:
5.41
4wg0M-4eaaA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 170
GLY A 172
ARG A 174
ILE A 186
ALA A 137
 COA  A 302 (-3.4A)
None
None
None
None
 0.82A 5bw4B-4eaaA:
undetectable		 5bw4B-4eaaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		3 / 3 LEU A  69
SER A  92
PHE A  91
 None
 0.67A 6fgcA-4eaaA:
undetectable		 6fgcA-4eaaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4eaa PEROSAMINE
N-ACETYLTRANSFERASE
(Caulobacter
vibrioides) 		5 / 12 GLY A  74
GLY A  14
VAL A  22
ALA A  39
PHE A  70
 JB2  A 301 (-3.3A)
JB2  A 301 ( 4.1A)
None
JB2  A 301 (-3.5A)
None
 1.06A 6nj9K-4eaaA:
undetectable		 6nj9K-4eaaA:
21.22