SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		4 / 4 LEU A 525
SER A 466
TYR A 523
LEU A 515
 None
 1.18A 1xz1A-4eagA:
undetectable		 1xz1A-4eagA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		4 / 4 LEU A 525
SER A 466
TYR A 523
LEU A 515
 None
 1.18A 1xz3A-4eagA:
undetectable		 1xz3A-4eagA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		4 / 5 SER A 468
ASP A 472
PRO A 470
SER A 466
 None
 1.42A 2hdnA-4eagA:
undetectable
2hdnB-4eagA:
undetectable
2hdnD-4eagA:
undetectable		 2hdnA-4eagA:
14.62
2hdnB-4eagA:
18.61
2hdnD-4eagA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		4 / 5 SER A 466
SER A 468
ASP A 472
PRO A 470
 None
 1.40A 2hdnB-4eagA:
undetectable
2hdnC-4eagA:
undetectable
2hdnD-4eagA:
undetectable		 2hdnB-4eagA:
18.61
2hdnC-4eagA:
14.62
2hdnD-4eagA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		4 / 6 LEU A 525
SER A 466
TYR A 523
LEU A 515
 None
 1.15A 3rd0A-4eagA:
undetectable		 3rd0A-4eagA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		5 / 12 PHE A 569
ILE A 473
PHE A 527
ALA A 581
ALA A 575
 None
 1.35A 3ua1A-4eagA:
undetectable		 3ua1A-4eagA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4eag EG:132E8.2 PROTEIN
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1
(Drosophila
melanogaster;
Rattus
norvegicus) 		4 / 4 CYH A 573
LEU B 239
LEU B 251
ALA B 241
 None
 1.09A 5hpuA-4eagA:
undetectable
5hpuB-4eagA:
undetectable		 5hpuA-4eagA:
9.84
5hpuB-4eagA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4eag EG:132E8.2 PROTEIN
(Drosophila
melanogaster) 		5 / 12 ILE A 464
MET A 474
ALA A 575
ILE A 577
CYH A 573
 None
 1.37A 5mlmA-4eagA:
undetectable		 5mlmA-4eagA:
14.07