SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 SER A 404
ASP A 408
PRO A 406
SER A 402
 None
 1.39A 2hdnA-4ealA:
undetectable
2hdnB-4ealA:
undetectable
2hdnD-4ealA:
undetectable		 2hdnA-4ealA:
12.26
2hdnB-4ealA:
15.76
2hdnD-4ealA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 5 SER A 402
SER A 404
ASP A 408
PRO A 406
 None
 1.34A 2hdnB-4ealA:
undetectable
2hdnC-4ealA:
undetectable
2hdnD-4ealA:
undetectable		 2hdnB-4ealA:
15.76
2hdnC-4ealA:
12.26
2hdnD-4ealA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Rattus
norvegicus) 		4 / 8 TYR A 422
LEU A 542
ALA A 540
MET A 447
 None
 1.08A 2wekA-4ealA:
undetectable		 2wekA-4ealA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 ARG A 464
HIS B 238
SER A 448
 None
 0.98A 4mjwA-4ealA:
4.7
4mjwB-4ealA:
5.3		 4mjwA-4ealA:
12.18
4mjwB-4ealA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 SER A 448
ARG A 464
HIS B 238
 None
 0.98A 4mjwA-4ealA:
4.7
4mjwB-4ealA:
5.3		 4mjwA-4ealA:
12.18
4mjwB-4ealA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4eal 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 4 CYH A 539
LEU B 239
LEU B 251
ALA B 241
 None
 1.07A 5hpuA-4ealA:
undetectable
5hpuB-4ealA:
undetectable		 5hpuA-4ealA:
13.13
5hpuB-4ealA:
11.65