SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 ALA A 146
ASP A 149
ARG A 246
ILE A 177
LEU A 108
 None
 1.26A 1d1gA-4eayA:
undetectable		 1d1gA-4eayA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.90A 1dmaB-4eayA:
undetectable		 1dmaB-4eayA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A 239
ASP A 320
ASN A 318
 None
 0.90A 1nbhA-4eayA:
undetectable		 1nbhA-4eayA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A 239
ASP A 320
ASN A 318
 None
 0.90A 1nbhD-4eayA:
undetectable		 1nbhD-4eayA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A 239
THR A 302
VAL A 277
 None
 0.79A 2q64A-4eayA:
undetectable		 2q64A-4eayA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 ARG A 239
THR A 302
VAL A 277
 None
 0.69A 2qakA-4eayA:
undetectable		 2qakA-4eayA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A  28
GLU A  63
HIS A 233
ASP A 236
ASP A 351
 None
CS2  A 402 (-3.6A)
MN  A 403 ( 3.4A)
CS2  A 402 (-3.7A)
CS2  A 402 (-2.7A)
 1.27A 2xinC-4eayA:
20.2		 2xinC-4eayA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 GLN A  80
ALA A  83
GLN A  86
ARG A  90
 None
 1.26A 2z0aA-4eayA:
undetectable		 2z0aA-4eayA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 GLN A  86
ALA A  83
GLN A  80
ILE A  82
 None
 1.24A 2z0aA-4eayA:
undetectable		 2z0aA-4eayA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 GLU A  63
VAL A  62
CYH A 101
 CS2  A 402 (-3.6A)
None
CS2  A 402 ( 4.3A)
 1.01A 3fbxA-4eayA:
undetectable		 3fbxA-4eayA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 11 GLY A 353
GLY A 367
ALA A 125
ALA A 315
ALA A 370
 None
 1.04A 3g88A-4eayA:
undetectable		 3g88A-4eayA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 11 GLY A 353
GLY A 367
ALA A 125
ALA A 315
ALA A 370
 None
 1.03A 3g88B-4eayA:
undetectable		 3g88B-4eayA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 353
GLY A 367
ALA A 125
ALA A 315
ALA A 370
 None
 1.04A 3g89A-4eayA:
undetectable		 3g89A-4eayA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 353
GLY A 367
ALA A 125
ALA A 315
ALA A 370
 None
 1.08A 3g8bA-4eayA:
undetectable		 3g8bA-4eayA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 353
GLY A 367
ALA A 125
ALA A 315
ALA A 370
 None
 1.06A 3g8bB-4eayA:
undetectable		 3g8bB-4eayA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 ILE A 241
PHE A 136
LEU A 197
ILE A 178
THR A 113
 None
 1.15A 3qfxA-4eayA:
undetectable		 3qfxA-4eayA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 ILE A 241
PHE A 136
LEU A 197
ILE A 178
THR A 113
 None
 1.15A 3qfxB-4eayA:
undetectable		 3qfxB-4eayA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 ASN A 211
PHE A 212
ALA A 213
THR A 260
 None
 0.90A 3t3sB-4eayA:
undetectable		 3t3sB-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 ASN A 211
PHE A 212
ALA A 213
THR A 260
 None
 0.96A 3t3sC-4eayA:
undetectable		 3t3sC-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASN A 211
PHE A 212
ALA A 213
THR A 260
 None
 0.94A 3t3sD-4eayA:
undetectable		 3t3sD-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 ASN A 211
PHE A 212
ALA A 213
THR A 260
 None
 0.91A 3t3sE-4eayA:
undetectable		 3t3sE-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 ASN A 211
PHE A 212
ALA A 213
THR A 260
 None
 1.04A 4ejgA-4eayA:
undetectable		 4ejgA-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.83A 4hyfA-4eayA:
undetectable		 4hyfA-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.89A 4hyfB-4eayA:
undetectable		 4hyfB-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.84A 4hyfC-4eayA:
undetectable		 4hyfC-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 PRO A 245
LEU A 244
HIS A 196
 None
 0.67A 4pevA-4eayA:
undetectable		 4pevA-4eayA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 LEU A 197
THR A 111
ILE A 241
ILE A 177
PHE A 136
 None
 1.20A 4rp8C-4eayA:
undetectable		 4rp8C-4eayA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 ASN A 281
ASP A 280
ARG A 304
ARG A 278
 None
 1.36A 6dwdB-4eayA:
undetectable
6dwdD-4eayA:
undetectable		 6dwdB-4eayA:
23.74
6dwdD-4eayA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 5 ARG A 304
ARG A 278
ASN A 281
ASP A 280
 None
 1.36A 6dwjB-4eayA:
undetectable
6dwjD-4eayA:
undetectable		 6dwjB-4eayA:
23.74
6dwjD-4eayA:
23.74