SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4eb0 LCC
(uncultured
bacterium) 		3 / 3 TRP A 259
ALA A 160
VAL A 185
 None
 0.96A 1bdwA-4eb0A:
undetectable
1bdwB-4eb0A:
undetectable		 1bdwA-4eb0A:
16.67
1bdwB-4eb0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4eb0 LCC
(uncultured
bacterium) 		5 / 11 TYR A  77
GLY A  87
LEU A 154
VAL A  58
PRO A  79
 None
 1.50A 1i9jH-4eb0A:
undetectable
1i9jL-4eb0A:
undetectable		 1i9jH-4eb0A:
25.82
1i9jL-4eb0A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 4eb0 LCC
(uncultured
bacterium) 		5 / 11 VAL A 118
TYR A  77
GLY A  87
LEU A 154
VAL A  58
 None
 1.35A 1i9jH-4eb0A:
undetectable
1i9jL-4eb0A:
undetectable		 1i9jH-4eb0A:
25.82
1i9jL-4eb0A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4eb0 LCC
(uncultured
bacterium) 		4 / 7 THR A 144
SER A 145
ARG A 143
LEU A 181
 SCN  A 303 (-4.7A)
SCN  A 303 (-2.7A)
None
None
 0.94A 1ibgL-4eb0A:
undetectable		 1ibgL-4eb0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4eb0 LCC
(uncultured
bacterium) 		4 / 5 PHE A 114
LEU A 139
MET A  91
LEU A 203
 None
 1.43A 1skxA-4eb0A:
undetectable		 1skxA-4eb0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4eb0 LCC
(uncultured
bacterium) 		3 / 3 ALA A 160
VAL A 185
TRP A 259
 None
 0.92A 1w5uA-4eb0A:
undetectable
1w5uB-4eb0A:
undetectable		 1w5uA-4eb0A:
16.67
1w5uB-4eb0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4eb0 LCC
(uncultured
bacterium) 		3 / 3 TRP A 259
ALA A 160
VAL A 185
 None
 1.00A 1w5uA-4eb0A:
undetectable
1w5uB-4eb0A:
undetectable		 1w5uA-4eb0A:
16.67
1w5uB-4eb0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 GLY A 169
GLY A 170
VAL A 161
LEU A 135
LEU A 181
 None
 1.16A 1ya4B-4eb0A:
13.9		 1ya4B-4eb0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4eb0 LCC
(uncultured
bacterium) 		4 / 8 LEU A 237
ASN A 246
HIS A 164
ALA A 207
 None
 0.92A 2bnnA-4eb0A:
undetectable
2bnnB-4eb0A:
undetectable		 2bnnA-4eb0A:
24.91
2bnnB-4eb0A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4eb0 LCC
(uncultured
bacterium) 		3 / 3 TRP A 259
ALA A 160
VAL A 185
 None
 0.85A 2izqC-4eb0A:
undetectable
2izqD-4eb0A:
undetectable		 2izqC-4eb0A:
16.67
2izqD-4eb0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4eb0 LCC
(uncultured
bacterium) 		4 / 5 PRO A 214
PRO A 189
ILE A 204
GLY A 206
 None
 1.12A 2jkjD-4eb0A:
undetectable		 2jkjD-4eb0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4eb0 LCC
(uncultured
bacterium) 		4 / 5 PRO A 214
PRO A 189
ILE A 204
GLY A 206
 None
 1.12A 2jkjF-4eb0A:
undetectable		 2jkjF-4eb0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4eb0 LCC
(uncultured
bacterium) 		4 / 6 ALA A 240
ASN A 249
PRO A 245
ALA A 244
 None
 1.18A 2zgwB-4eb0A:
undetectable		 2zgwB-4eb0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 GLN A 134
PHE A 125
ASN A 120
GLY A  72
ARG A  65
 None
SCN  A 302 ( 4.8A)
None
None
None
 1.37A 3aodC-4eb0A:
undetectable		 3aodC-4eb0A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
GLY A 167
GLY A 168
ALA A 132
ASP A 129
 None
 1.21A 3i5uA-4eb0A:
2.3		 3i5uA-4eb0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4eb0 LCC
(uncultured
bacterium) 		3 / 3 TRP A 259
ALA A 160
VAL A 185
 None
 0.89A 3l8lC-4eb0A:
undetectable
3l8lD-4eb0A:
undetectable		 3l8lC-4eb0A:
16.67
3l8lD-4eb0A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4eb0 LCC
(uncultured
bacterium) 		4 / 4 ASN A 288
SER A 258
LEU A 274
THR A 230
 None
 1.43A 4an2A-4eb0A:
undetectable		 4an2A-4eb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
VAL A 202
PRO A 186
HIS A 242
GLY A  94
 None
 1.19A 4hvcB-4eb0A:
3.9		 4hvcB-4eb0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 ARG A  65
GLY A  70
GLN A 134
ALA A  99
GLY A  74
 None
 1.11A 4r29A-4eb0A:
undetectable		 4r29A-4eb0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 GLY A 163
LEU A 172
ALA A 175
THR A 198
ALA A 184
 None
 1.08A 4uckB-4eb0A:
undetectable		 4uckB-4eb0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 ILE A  89
LEU A 109
GLY A  42
PRO A  43
LEU A 142
 None
None
SCN  A 301 (-3.6A)
None
None
 1.20A 5ienA-4eb0A:
undetectable		 5ienA-4eb0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
VAL A 202
PRO A 186
HIS A 242
GLY A  94
 None
 1.18A 5xipA-4eb0A:
3.9		 5xipA-4eb0A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
VAL A 202
PRO A 186
HIS A 242
GLY A  94
 None
 1.14A 5xiqA-4eb0A:
4.0		 5xiqA-4eb0A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
VAL A 202
PRO A 186
HIS A 242
GLY A  94
 None
 1.10A 5xiqD-4eb0A:
3.3		 5xiqD-4eb0A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 GLY A  74
GLY A  72
ILE A  76
LEU A 117
PRO A 147
 None
 1.15A 6b3aA-4eb0A:
undetectable		 6b3aA-4eb0A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 GLY A  74
GLY A  72
ILE A  76
LEU A 117
PRO A 147
 None
 1.18A 6b3bA-4eb0A:
undetectable		 6b3bA-4eb0A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4eb0 LCC
(uncultured
bacterium) 		5 / 12 PHE A 196
VAL A 202
PRO A 186
HIS A 242
GLY A  94
 None
 1.09A 6mn8A-4eb0A:
undetectable		 6mn8A-4eb0A:
18.09