SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 8 VAL A 224
ASN A 225
GLY A 234
LEU A 236
 None
 0.94A 1dzmA-4ebaA:
undetectable		 1dzmA-4ebaA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15
(Kluyveromyces
lactis) 		5 / 8 PHE G 161
ILE G 175
LEU G 178
LEU A 654
LEU G 146
 None
 1.42A 1eupA-4ebaG:
undetectable		 1eupA-4ebaG:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 6 TRP A 170
PHE A 169
GLU A 163
ILE A 161
 None
 1.47A 1nsiA-4ebaA:
undetectable
1nsiB-4ebaA:
undetectable		 1nsiA-4ebaA:
20.18
1nsiB-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 6 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.49A 1nsiC-4ebaA:
undetectable
1nsiD-4ebaA:
undetectable		 1nsiC-4ebaA:
20.18
1nsiD-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 8 PHE A 526
LEU A 522
ILE A 516
LYS A 515
 None
 0.84A 1sbrA-4ebaA:
undetectable		 1sbrA-4ebaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		3 / 3 TRP A 250
LEU A 246
LYS A 298
 None
 1.40A 1yajK-4ebaA:
undetectable		 1yajK-4ebaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.43A 2nsiA-4ebaA:
undetectable
2nsiB-4ebaA:
undetectable		 2nsiA-4ebaA:
20.18
2nsiB-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 TRP A 170
PHE A 169
GLU A 163
ILE A 161
 None
 1.45A 2nsiA-4ebaA:
undetectable
2nsiB-4ebaA:
undetectable		 2nsiA-4ebaA:
20.18
2nsiB-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.46A 2nsiC-4ebaA:
undetectable
2nsiD-4ebaA:
undetectable		 2nsiC-4ebaA:
20.18
2nsiD-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 TRP A 170
PHE A 169
GLU A 163
ILE A 161
 None
 1.47A 2nsiC-4ebaA:
undetectable
2nsiD-4ebaA:
undetectable		 2nsiC-4ebaA:
20.18
2nsiD-4ebaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 12 GLN A 168
GLN A 316
ASP A 120
LEU A 125
SER A 126
 None
 1.33A 2nv4A-4ebaA:
undetectable		 2nv4A-4ebaA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 12 TYR A 419
ASP A 388
SER A 435
TYR A 422
ILE A 438
 None
 1.40A 3b7pC-4ebaA:
undetectable		 3b7pC-4ebaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.45A 3e7gA-4ebaA:
undetectable
3e7gB-4ebaA:
undetectable		 3e7gA-4ebaA:
21.11
3e7gB-4ebaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 TRP A 170
PHE A 169
GLU A 163
ILE A 161
 None
 1.46A 3e7gA-4ebaA:
undetectable
3e7gB-4ebaA:
undetectable		 3e7gA-4ebaA:
21.11
3e7gB-4ebaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 7 ILE A 161
TRP A 170
PHE A 169
GLU A 163
 None
 1.46A 3e7gC-4ebaA:
undetectable
3e7gD-4ebaA:
undetectable		 3e7gC-4ebaA:
21.11
3e7gD-4ebaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 8 TRP A 170
PHE A 169
GLU A 163
ILE A 161
 None
 1.46A 3e7gC-4ebaA:
undetectable
3e7gD-4ebaA:
undetectable		 3e7gC-4ebaA:
21.11
3e7gD-4ebaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 10 LEU A 261
ALA A  82
ILE A  84
LEU A  74
PHE A  78
 None
 1.12A 3fl9A-4ebaA:
undetectable		 3fl9A-4ebaA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 12 LEU A 261
LEU A 273
ILE A  84
LEU A  74
PHE A  78
 None
 1.07A 3fl9G-4ebaA:
undetectable		 3fl9G-4ebaA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 4 GLY A 486
GLU A 487
ASP A 494
ASP A 518
 None
 1.41A 3mb5A-4ebaA:
undetectable		 3mb5A-4ebaA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 10 ILE A 429
ALA A 434
MET A 423
SER A 465
ILE A 464
 None
 1.21A 3qg2A-4ebaA:
undetectable		 3qg2A-4ebaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4eba RNA15
(Kluyveromyces
lactis) 		4 / 4 LEU G 138
GLY G 136
LEU G 135
GLU G 134
 None
 1.05A 3tgvB-4ebaG:
undetectable		 3tgvB-4ebaG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		3 / 3 PRO A 451
ASP A 452
GLU A 487
 None
 0.84A 3v4tC-4ebaA:
undetectable		 3v4tC-4ebaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		5 / 12 ILE A 263
ALA A  82
ASP A 120
LEU A 121
ILE A 128
 None
 1.39A 4gh8B-4ebaA:
undetectable		 4gh8B-4ebaA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 5 LEU A 508
ASP A 494
GLU A 501
VAL A 536
 None
 1.25A 4nkvA-4ebaA:
undetectable		 4nkvA-4ebaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 6 ASN A 457
MET A 423
TYR A 459
GLU A 461
 None
 1.40A 4r87H-4ebaA:
undetectable		 4r87H-4ebaA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		3 / 3 ASP A 570
ASN A 572
PHE A 532
 None
 0.75A 5jglB-4ebaA:
undetectable		 5jglB-4ebaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		5 / 12 LEU G 164
ALA G 168
LEU G 179
ILE A 627
LEU A 654
 None
 1.07A 5ljeA-4ebaG:
undetectable		 5ljeA-4ebaG:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
(Kluyveromyces
lactis) 		4 / 6 LEU A  89
SER A  90
PHE A  93
ASP A  94
 None
 0.88A 5om3A-4ebaA:
undetectable
5om3B-4ebaA:
undetectable		 5om3A-4ebaA:
8.40
5om3B-4ebaA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		3 / 3 LEU G 171
GLN G 170
LYS A 624
 None
 0.79A 6exiB-4ebaG:
undetectable		 6exiB-4ebaG:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		3 / 3 LEU G 171
GLN G 170
LYS A 624
 None
 0.85A 6exiA-4ebaG:
undetectable		 6exiA-4ebaG:
19.11