SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ALA A  70
VAL A  65
TRP A  66
 None
 0.90A 1bdwA-4ecaA:
undetectable
1bdwB-4ecaA:
undetectable		 1bdwA-4ecaA:
3.67
1bdwB-4ecaA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ASN A  34
ALA A  14
ASN A  55
 None
 0.79A 1n4fA-4ecaA:
undetectable		 1n4fA-4ecaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ASP A 156
THR A 201
PRO A 202
 None
 0.72A 2pynB-4ecaA:
undetectable		 2pynB-4ecaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 ASP A 156
THR A 201
PRO A 202
 None
 0.69A 2qakB-4ecaA:
undetectable		 2qakB-4ecaA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 LEU A 129
VAL A 110
LEU A  42
ILE A 187
ILE A   4
 None
 1.12A 2uxoB-4ecaA:
undetectable		 2uxoB-4ecaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 THR A  86
SER A 118
THR A  26
GLY A  88
ALA A 114
 None
AEI  A  12 ( 4.5A)
None
AEI  A  12 ( 3.2A)
AEI  A  12 ( 4.4A)
 1.14A 2x2iA-4ecaA:
undetectable		 2x2iA-4ecaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 8 SER A 271
ARG A 269
THR A 278
ALA A 282
 None
 1.00A 3ax7A-4ecaA:
undetectable		 3ax7A-4ecaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 9 THR A  86
VAL A 148
SER A 173
ILE A  13
GLY A  88
 None
None
None
AEI  A  12 ( 4.4A)
AEI  A  12 ( 3.2A)
 1.24A 3cv9A-4ecaA:
undetectable		 3cv9A-4ecaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 ASP A 204
LEU A 308
PHE A  98
LEU A 208
SER A 206
 None
 1.25A 3o94B-4ecaA:
undetectable		 3o94B-4ecaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 ASP A 204
LEU A 308
PHE A  98
LEU A 208
SER A 206
 None
 1.28A 3o94C-4ecaA:
undetectable		 3o94C-4ecaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 11 ASP A 204
LEU A 308
PHE A  98
LEU A 208
SER A 206
 None
 1.28A 3o94D-4ecaA:
undetectable		 3o94D-4ecaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 8 ASP A 124
ALA A 123
SER A 120
TYR A  25
 None
None
None
AEI  A  12 (-4.0A)
 1.10A 3rodA-4ecaA:
undetectable		 3rodA-4ecaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		3 / 3 TYR A  25
ASP A  90
ASP A  60
 AEI  A  12 (-4.0A)
AEI  A  12 (-2.7A)
None
 0.88A 4a6eA-4ecaA:
undetectable		 4a6eA-4ecaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 ALA A 228
LEU A 226
SER A 224
SER A 252
 None
 1.16A 4iklA-4ecaA:
undetectable
4iklB-4ecaA:
undetectable		 4iklA-4ecaA:
18.10
4iklB-4ecaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		4 / 7 VAL A 217
ILE A 216
LEU A 310
LEU A 306
 None
 1.03A 4l1wA-4ecaA:
undetectable		 4l1wA-4ecaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		6 / 11 GLY A  50
ILE A  85
ILE A  73
GLY A  82
ILE A   4
VAL A 112
 None
 1.37A 4q1xA-4ecaA:
undetectable		 4q1xA-4ecaA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4eca L-ASPARAGINE
AMIDOHYDROLASE
(Escherichia
coli) 		5 / 12 LEU A  35
GLY A 125
GLY A 113
VAL A 112
THR A  86
 None
 1.04A 5o4yD-4ecaA:
undetectable
5o4yE-4ecaA:
undetectable		 5o4yD-4ecaA:
4.82
5o4yE-4ecaA:
16.13