SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 11 GLY A 266
ALA A 247
THR A 362
VAL A 311
ILE A 309
 None
 1.15A 2nnhA-4ecdA:
undetectable		 2nnhA-4ecdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		4 / 5 LEU A 248
ILE A 234
SER A 304
GLY A 298
 None
 0.93A 2otfA-4ecdA:
undetectable		 2otfA-4ecdA:
13.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		6 / 11 THR A 140
ILE A 255
MET A 315
ALA A 347
ALA A 351
VAL A 354
 None
 0.72A 2qhfA-4ecdA:
36.2		 2qhfA-4ecdA:
59.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 12 GLN A 307
VAL A 225
VAL A 359
LEU A 363
ILE A 160
 None
 1.08A 3gwxB-4ecdA:
undetectable		 3gwxB-4ecdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		3 / 3 PRO A 317
PHE A 258
ALA A 351
 None
 0.69A 3itaD-4ecdA:
undetectable		 3itaD-4ecdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 11 LEU A 248
ILE A 309
ALA A 364
ALA A 227
THR A 162
 None
 1.00A 3mdtB-4ecdA:
undetectable		 3mdtB-4ecdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		4 / 5 LEU A 226
ARG A 312
LEU A 180
PRO A 181
 None
 1.37A 3onnA-4ecdA:
undetectable		 3onnA-4ecdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		4 / 4 ASN A 305
GLY A 298
GLU A 300
LYS A 295
 None
 1.25A 3r2cA-4ecdA:
0.0		 3r2cA-4ecdA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		4 / 5 GLY A 306
LEU A 248
ILE A 234
LEU A 180
 None
 0.88A 4o8fA-4ecdA:
undetectable		 4o8fA-4ecdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 11 LEU A 244
GLU A 356
ALA A 364
LEU A 363
TYR A 366
 None
 1.11A 4wg0H-4ecdA:
undetectable
4wg0I-4ecdA:
undetectable
4wg0J-4ecdA:
undetectable		 4wg0H-4ecdA:
2.37
4wg0I-4ecdA:
2.37
4wg0J-4ecdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		4 / 6 SER A 192
GLY A  47
ASP A 344
ARG A  46
 None
 0.93A 5cdnC-4ecdA:
2.1
5cdnD-4ecdA:
undetectable		 5cdnC-4ecdA:
23.26
5cdnD-4ecdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 12 LEU A 361
ALA A 357
ALA A  17
ILE A  19
ILE A  75
 None
 0.80A 5itzB-4ecdA:
undetectable		 5itzB-4ecdA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 12 PRO A 349
GLY A 220
SER A 352
VAL A 194
GLY A 221
 None
None
None
None
CL  A 402 (-3.5A)
 0.93A 5wyqA-4ecdA:
undetectable		 5wyqA-4ecdA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4ecd CHORISMATE SYNTHASE
(Bifidobacterium
longum) 		5 / 11 GLY A 373
LEU A 368
ALA A 367
ALA A 157
PHE A 153
 None
 1.08A 6qgbE-4ecdA:
undetectable		 6qgbE-4ecdA:
22.02