SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		3 / 3 TRP A 234
VAL A 224
TRP A 231
 None
None
EDO  A 304 ( 4.3A)
 1.42A 1gmkC-4ecfA:
undetectable
1gmkD-4ecfA:
undetectable		 1gmkC-4ecfA:
6.67
1gmkD-4ecfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 ASP A  88
GLY A  51
VAL A  47
TYR A 271
ALA A 203
 PO4  A 300 (-2.9A)
None
None
None
None
 0.95A 1pbkA-4ecfA:
undetectable		 1pbkA-4ecfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		6 / 11 GLY A 197
ALA A 198
VAL A 188
ILE A 115
ILE A 133
ILE A 154
 None
 1.08A 1sdvB-4ecfA:
undetectable		 1sdvB-4ecfA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		4 / 6 TYR A 271
GLY A 186
SER A 184
ARG A 189
 None
None
None
ACT  A 301 (-3.1A)
 1.39A 2a3cA-4ecfA:
undetectable		 2a3cA-4ecfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 10 TYR A 201
GLY A 159
GLY A 161
THR A 162
ALA A 164
 None
None
PO4  A 300 (-3.6A)
PO4  A 300 (-3.5A)
None
 1.07A 2ej3B-4ecfA:
undetectable		 2ej3B-4ecfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		4 / 7 GLN A  53
TYR A 255
TYR A  54
ILE A  84
 None
 1.35A 2ph9A-4ecfA:
undetectable
2ph9B-4ecfA:
undetectable		 2ph9A-4ecfA:
20.85
2ph9B-4ecfA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		3 / 3 SER A 184
THR A 162
PHE A 134
 None
PO4  A 300 (-3.5A)
None
 0.77A 2x91A-4ecfA:
undetectable		 2x91A-4ecfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 6 GLY A  67
GLY A  39
GLY A  73
GLY A  68
GLY A  71
 None
 1.09A 3bogA-4ecfA:
undetectable
3bogC-4ecfA:
undetectable		 3bogA-4ecfA:
undetectable
3bogC-4ecfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		6 / 12 GLY A 197
ALA A 198
VAL A 188
ILE A 115
ILE A 133
ILE A 154
 None
 1.30A 3el1B-4ecfA:
undetectable		 3el1B-4ecfA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 11 ALA A  49
ASN A  64
VAL A 256
ASN A  86
ILE A  84
 None
 1.28A 3jw5A-4ecfA:
undetectable		 3jw5A-4ecfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		3 / 3 SER A 160
GLY A 161
THR A 162
 PO4  A 300 (-2.6A)
PO4  A 300 (-3.6A)
PO4  A 300 (-3.5A)
 0.06A 3k9wA-4ecfA:
undetectable		 3k9wA-4ecfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		4 / 7 TYR A 255
VAL A 103
VAL A 107
ILE A  84
 None
 1.09A 3mssB-4ecfA:
undetectable		 3mssB-4ecfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLY A 170
ALA A 172
PHE A 169
ASN A 173
ILE A 233
 EDO  A 310 (-4.0A)
EDO  A 310 (-3.6A)
None
None
None
 1.26A 4azsA-4ecfA:
undetectable		 4azsA-4ecfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLY A  51
ALA A  50
VAL A 256
LEU A 239
ILE A  35
 None
 1.21A 4pd5A-4ecfA:
undetectable		 4pd5A-4ecfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLY A  51
ALA A  50
VAL A 256
LEU A 239
ILE A  35
 None
 1.22A 4pd9A-4ecfA:
undetectable		 4pd9A-4ecfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLN A 129
ILE A 199
ASN A 217
LEU A 216
GLY A 170
 None
None
EDO  A 304 (-3.9A)
EDO  A 304 (-4.2A)
EDO  A 310 (-4.0A)
 1.12A 4r38B-4ecfA:
undetectable		 4r38B-4ecfA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLN A 129
ILE A 199
ASN A 217
LEU A 216
GLY A 170
 None
None
EDO  A 304 (-3.9A)
EDO  A 304 (-4.2A)
EDO  A 310 (-4.0A)
 1.21A 4r38C-4ecfA:
undetectable		 4r38C-4ecfA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLN A 129
ILE A 199
ASN A 217
LEU A 216
GLY A 170
 None
None
EDO  A 304 (-3.9A)
EDO  A 304 (-4.2A)
EDO  A 310 (-4.0A)
 1.19A 4r38D-4ecfA:
undetectable		 4r38D-4ecfA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 LEU A  46
LEU A 239
THR A  61
VAL A  65
ALA A  37
 None
 0.92A 4x1yD-4ecfA:
undetectable		 4x1yD-4ecfA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 11 ASP A  88
ALA A  37
GLY A  68
SER A  87
GLY A  85
 PO4  A 300 (-2.9A)
None
None
None
None
 1.26A 4xnxA-4ecfA:
undetectable		 4xnxA-4ecfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 12 GLY A  96
ILE A  97
THR A  70
GLY A  69
GLY A  39
 None
None
PO4  A 300 (-3.6A)
PO4  A 300 (-3.4A)
None
 0.82A 5koxA-4ecfA:
undetectable		 5koxA-4ecfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		4 / 5 GLU A 237
GLY A 161
SER A  40
GLY A  69
 None
PO4  A 300 (-3.6A)
PO4  A 300 (-2.9A)
PO4  A 300 (-3.4A)
 1.07A 5kprA-4ecfA:
undetectable		 5kprA-4ecfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 10 GLY A  68
GLY A  67
LEU A  89
LEU A  74
THR A  72
 None
 1.04A 5o96G-4ecfA:
undetectable
5o96H-4ecfA:
undetectable		 5o96G-4ecfA:
22.68
5o96H-4ecfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		5 / 10 GLY A  68
GLY A  67
LEU A  89
LEU A  74
THR A  72
 None
 0.96A 5vm8B-4ecfA:
undetectable		 5vm8B-4ecfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Lactobacillus
brevis) 		4 / 6 ASN A 263
VAL A 266
LEU A 269
GLN A 262
 None
 1.35A 5xdhA-4ecfA:
undetectable
5xdhC-4ecfA:
undetectable		 5xdhA-4ecfA:
12.80
5xdhC-4ecfA:
12.80