SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		3 / 3 ALA A 297
VAL A 277
TRP A 280
 None
 0.93A 1c4dA-4ecgA:
undetectable
1c4dB-4ecgA:
undetectable		 1c4dA-4ecgA:
5.22
1c4dB-4ecgA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 11 ALA A 173
LEU A 199
LEU A 177
LEU A  96
ALA A  83
 None
 0.95A 1h9zA-4ecgA:
undetectable		 1h9zA-4ecgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 11 ALA A 173
LEU A 199
LEU A 177
LEU A  96
ALA A  83
 None
 0.94A 1ha2A-4ecgA:
undetectable		 1ha2A-4ecgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 12 ALA A 241
GLY A 220
VAL A 120
LEU A 123
ALA A 124
 None
 1.19A 1jipA-4ecgA:
undetectable		 1jipA-4ecgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		4 / 8 ASP A 127
TYR A  70
LEU A 213
ASP A 209
 CA  A 503 ( 4.1A)
None
None
None
 1.05A 1rmtD-4ecgA:
undetectable		 1rmtD-4ecgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		3 / 3 SER A 113
GLU A 299
ASP A 275
 None
CA  A 504 (-3.4A)
CA  A 506 (-3.0A)
 0.75A 2zulA-4ecgA:
undetectable		 2zulA-4ecgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 12 ALA A 320
GLY A 324
LEU A 337
SER A 336
LEU A 394
 None
 1.35A 3bxoA-4ecgA:
undetectable		 3bxoA-4ecgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		3 / 3 SER A 113
GLU A 299
ASP A 275
 None
CA  A 504 (-3.4A)
CA  A 506 (-3.0A)
 0.75A 3dmhA-4ecgA:
undetectable		 3dmhA-4ecgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		3 / 3 ASP A 357
LYS A 358
ASP A 361
 None
 0.79A 4a7tA-4ecgA:
undetectable		 4a7tA-4ecgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		4 / 6 LEU A 117
MET A  73
LEU A 213
VAL A 226
 None
 1.15A 4okbA-4ecgA:
undetectable		 4okbA-4ecgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 8 ALA A 271
ASN A 256
GLU A 267
GLY A 263
THR A 391
 None
 0.99A 4r20A-4ecgA:
undetectable		 4r20A-4ecgA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		4 / 7 ASN A 194
LYS A 193
LEU A 177
PHE A 178
 None
 1.14A 4yv5A-4ecgA:
0.4		 4yv5A-4ecgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		3 / 3 ASP A 131
GLU A 158
SER A 303
 CA  A 504 (-3.3A)
None
None
 0.71A 5bw4B-4ecgA:
undetectable		 5bw4B-4ecgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 12 ALA A 115
PHE A  61
GLY A 323
LEU A 337
ILE A 317
 None
 1.00A 5m24A-4ecgA:
undetectable		 5m24A-4ecgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 12 ALA A 115
PHE A  61
GLY A 324
LEU A 337
ILE A 317
 None
 1.06A 5m24A-4ecgA:
undetectable		 5m24A-4ecgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4ecg PUTATIVE
IRON-REGULATED
PROTEIN A
(Parabacteroides
distasonis) 		5 / 12 GLY A 395
GLY A 260
GLY A 257
ASP A 127
ILE A 264
 None
None
None
CA  A 503 ( 4.1A)
None
 1.02A 5njvD-4ecgA:
undetectable		 5njvD-4ecgA:
21.02