SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 239
LEU A 224
GLY A 226
LEU A 228
 None
 0.93A 1gtiB-4eclA:
undetectable		 1gtiB-4eclA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 11 SER A 355
ALA A 353
LEU A 245
LEU A 247
LEU A 368
 None
 0.91A 2xn5A-4eclA:
undetectable		 2xn5A-4eclA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 TYR A  75
GLU A  48
ASN A 369
 None
 1.00A 2y7hC-4eclA:
undetectable		 2y7hC-4eclA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 LEU A 239
LEU A 241
ALA A 223
LEU A  82
HIS A 200
 None
 1.30A 3b0wA-4eclA:
undetectable		 3b0wA-4eclA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 280
VAL A 244
ILE A 336
ARG A 372
 None
 1.13A 3ik3A-4eclA:
undetectable		 3ik3A-4eclA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 280
VAL A 244
ILE A 336
ARG A 372
 None
 1.13A 3ik3B-4eclA:
undetectable		 3ik3B-4eclA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 11 VAL A  37
ALA A  41
GLY A  43
TYR A  75
TYR A  47
 None
 1.31A 3qxyB-4eclA:
undetectable
3qxyQ-4eclA:
undetectable		 3qxyB-4eclA:
23.39
3qxyQ-4eclA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 ALA A  39
LEU A   9
LEU A 247
GLY A 337
LYS A 338
 None
 1.15A 4l9qB-4eclA:
undetectable		 4l9qB-4eclA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 300
VAL A 299
PRO A 307
GLU A 342
 None
 1.13A 4lb2A-4eclA:
undetectable		 4lb2A-4eclA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 10 LEU A 335
ILE A 308
LEU A 292
LEU A 280
PHE A 288
 None
 1.03A 4odoC-4eclA:
undetectable		 4odoC-4eclA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 VAL A  20
LEU A  84
VAL A  37
ALA A  35
LEU A  33
 None
 1.12A 5iktA-4eclA:
undetectable		 5iktA-4eclA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 THR A 128
MET A 130
HIS A 131
 None
CL  A 401 ( 3.9A)
None
 1.02A 5uunA-4eclA:
undetectable		 5uunA-4eclA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		5 / 11 GLY A 337
GLU A 343
ALA A 346
SER A 246
LEU A 245
 None
 1.23A 5x6yA-4eclA:
undetectable		 5x6yA-4eclA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4ecl SERINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 GLY A 337
LYS A 338
ASN A  15
GLY A 226
 None
 0.59A 6n7fA-4eclA:
undetectable		 6n7fA-4eclA:
13.12