SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 394
ARG A 412
ILE A 580
TYR A 582
 None
 0.83A 11gsA-4ecnA:
undetectable		 11gsA-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 394
ARG A 412
ILE A 580
TYR A 582
 None
 0.84A 11gsB-4ecnA:
undetectable		 11gsB-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 201
ILE A 287
TYR A 252
VAL A 246
 None
 1.02A 1db1A-4ecnA:
undetectable		 1db1A-4ecnA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 141
LEU A 139
MET A  76
VAL A  74
 None
 0.91A 1fduB-4ecnA:
undetectable		 1fduB-4ecnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A 853
VAL A 872
CYH A 897
ALA A 899
 None
 1.13A 1mz9E-4ecnA:
undetectable		 1mz9E-4ecnA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A  82
LEU A 201
VAL A 188
PHE A 163
VAL A 237
 None
 1.45A 1q23E-4ecnA:
undetectable		 1q23E-4ecnA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 THR A  82
LEU A 201
VAL A 188
PHE A 163
VAL A 237
 None
 1.44A 1q23J-4ecnA:
undetectable		 1q23J-4ecnA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 CYH A 643
PHE A 666
PHE A 642
LEU A 659
 None
 1.06A 1qcaA-4ecnA:
undetectable		 1qcaA-4ecnA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 886
GLY A 896
LEU A 853
TYR A 884
 None
 1.01A 1s1xA-4ecnA:
undetectable		 1s1xA-4ecnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 845
ASP A 864
ASN A 820
 None
 0.83A 2bm9D-4ecnA:
undetectable		 2bm9D-4ecnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 875
SER A 874
LEU A 860
THR A 831
 None
 0.96A 2f78A-4ecnA:
undetectable		 2f78A-4ecnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 875
SER A 874
LEU A 860
THR A 831
 None
 1.07A 2f78B-4ecnA:
undetectable		 2f78B-4ecnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 384
SER A 381
VAL A 379
MET A 403
 None
 1.19A 2fb2B-4ecnA:
undetectable		 2fb2B-4ecnA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 394
ARG A 412
ILE A 580
TYR A 582
 None
 0.92A 2gssA-4ecnA:
undetectable		 2gssA-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 394
ARG A 412
ILE A 580
TYR A 582
 None
 0.92A 2gssB-4ecnA:
undetectable		 2gssB-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 672
SER A 704
ALA A 703
SER A 676
 None
 1.08A 2i91A-4ecnA:
undetectable		 2i91A-4ecnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 672
SER A 704
ALA A 703
SER A 676
 None
 1.08A 2i91B-4ecnA:
undetectable		 2i91B-4ecnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 619
CYH A 643
LEU A 652
VAL A 649
LEU A 616
 None
 1.35A 2prgB-4ecnA:
undetectable		 2prgB-4ecnA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 821
GLN A 892
PRO A 866
 None
 0.95A 2qhfA-4ecnA:
undetectable		 2qhfA-4ecnA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 722
ASN A 751
ILE A 730
ILE A 761
THR A 755
 None
 1.13A 2rlcA-4ecnA:
undetectable		 2rlcA-4ecnA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 372
ARG A 474
TYR A 508
TYR A 504
 None
 1.46A 2wb9A-4ecnA:
undetectable		 2wb9A-4ecnA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 886
GLY A 810
ILE A 837
LEU A 857
ILE A 841
 None
 0.97A 3adxB-4ecnA:
undetectable		 3adxB-4ecnA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 242
THR A 273
TYR A 244
ASN A 192
ILE A 275
 None
 1.27A 3fw1A-4ecnA:
undetectable		 3fw1A-4ecnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 244
VAL A 274
GLY A 242
VAL A 237
GLY A 159
 None
 1.32A 3km6A-4ecnA:
undetectable		 3km6A-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 TYR A 244
VAL A 274
GLY A 242
VAL A 237
GLY A 159
 None
 1.31A 3kmoA-4ecnA:
undetectable		 3kmoA-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 561
ILE A 550
LEU A 535
ASP A 570
SER A 596
 None
 1.27A 3ko0A-4ecnA:
undetectable
3ko0B-4ecnA:
undetectable
3ko0C-4ecnA:
undetectable
3ko0D-4ecnA:
undetectable		 3ko0A-4ecnA:
9.28
3ko0B-4ecnA:
9.28
3ko0C-4ecnA:
9.28
3ko0D-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 570
SER A 596
LEU A 561
ILE A 550
LEU A 535
 None
 1.27A 3ko0G-4ecnA:
undetectable
3ko0H-4ecnA:
undetectable
3ko0I-4ecnA:
undetectable
3ko0J-4ecnA:
undetectable		 3ko0G-4ecnA:
9.28
3ko0H-4ecnA:
9.28
3ko0I-4ecnA:
9.28
3ko0J-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 535
LEU A 561
ILE A 550
ASP A 570
SER A 596
 None
 1.25A 3ko0K-4ecnA:
undetectable
3ko0L-4ecnA:
undetectable
3ko0M-4ecnA:
undetectable
3ko0N-4ecnA:
undetectable		 3ko0K-4ecnA:
9.28
3ko0L-4ecnA:
9.28
3ko0M-4ecnA:
9.28
3ko0N-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 6 LEU A 548
SER A 547
PHE A 581
ILE A 550
PHE A 419
 None
 1.49A 3ko0S-4ecnA:
undetectable		 3ko0S-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 385
HIS A 414
MET A 418
 None
 0.79A 3mihA-4ecnA:
undetectable		 3mihA-4ecnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 PHE A 394
GLU A 525
HIS A 385
LEU A 399
SER A 381
 None
 1.48A 3o94D-4ecnA:
undetectable		 3o94D-4ecnA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 783
ALA A 808
ILE A 837
ILE A 811
LEU A 806
 None
 1.15A 3ogpB-4ecnA:
undetectable		 3ogpB-4ecnA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 783
ALA A 808
ILE A 837
ILE A 811
LEU A 806
 None
 1.09A 3ogqB-4ecnA:
undetectable		 3ogqB-4ecnA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 392
LEU A 393
THR A 320
 None
 0.82A 3oxcA-4ecnA:
undetectable		 3oxcA-4ecnA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 PRO A 726
SER A 725
ILE A 701
VAL A 706
VAL A 677
 None
 1.21A 3rf4A-4ecnA:
undetectable
3rf4C-4ecnA:
undetectable		 3rf4A-4ecnA:
8.73
3rf4C-4ecnA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 PRO A 726
SER A 725
ILE A 701
VAL A 706
VAL A 677
 None
 1.21A 3rf4A-4ecnA:
undetectable
3rf4B-4ecnA:
undetectable		 3rf4A-4ecnA:
8.73
3rf4B-4ecnA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 PRO A 726
SER A 725
ILE A 701
VAL A 706
VAL A 677
 None
 1.20A 3rf4B-4ecnA:
undetectable
3rf4C-4ecnA:
undetectable		 3rf4B-4ecnA:
8.73
3rf4C-4ecnA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 344
VAL A 345
TRP A 330
ASP A 346
 None
 1.23A 3vqrA-4ecnA:
undetectable		 3vqrA-4ecnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 186
LEU A 165
ILE A 287
VAL A 246
 None
 0.97A 4a9kB-4ecnA:
undetectable		 4a9kB-4ecnA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 415
TYR A 482
ASN A 553
ILE A 556
ILE A 493
 None
 1.44A 4eb6B-4ecnA:
undetectable
4eb6C-4ecnA:
undetectable		 4eb6B-4ecnA:
19.84
4eb6C-4ecnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 277
ALA A 130
VAL A 153
TYR A 118
 None
 1.08A 4ijiH-4ecnA:
undetectable		 4ijiH-4ecnA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 678
SER A 680
HIS A 656
SER A 655
 None
 1.27A 4k7gB-4ecnA:
undetectable		 4k7gB-4ecnA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 469
ALA A 505
SER A 502
TYR A 508
 None
 1.17A 4lv9A-4ecnA:
undetectable
4lv9B-4ecnA:
undetectable		 4lv9A-4ecnA:
21.31
4lv9B-4ecnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 508
SER A 469
ALA A 505
SER A 502
 None
 1.19A 4lv9A-4ecnA:
undetectable
4lv9B-4ecnA:
undetectable		 4lv9A-4ecnA:
21.31
4lv9B-4ecnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 122
ASN A 277
ALA A 130
TYR A 119
 None
 0.90A 4mdbA-4ecnA:
undetectable		 4mdbA-4ecnA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 388
PHE A 419
ASN A 485
TYR A 527
 None
 1.41A 4mf6A-4ecnA:
undetectable		 4mf6A-4ecnA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 305
ALA A 301
ALA A 370
GLN A 373
ILE A 465
 None
 1.15A 4nqaH-4ecnA:
undetectable		 4nqaH-4ecnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 894
ASP A 889
ILE A 841
ILE A 870
THR A 891
 None
 1.36A 4p68A-4ecnA:
undetectable		 4p68A-4ecnA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 605
GLY A 584
CYH A 608
ALA A 551
ASN A 553
 None
 1.27A 4pclB-4ecnA:
undetectable		 4pclB-4ecnA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 729
ASN A 702
PHE A 666
 None
 0.83A 4pd9A-4ecnA:
undetectable		 4pd9A-4ecnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 436
GLN A 838
VAL A 788
SER A 429
LEU A 836
 None
 1.44A 4qztA-4ecnA:
undetectable		 4qztA-4ecnA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 294
ARG A 352
GLN A 507
 None
 0.65A 4rtbA-4ecnA:
undetectable		 4rtbA-4ecnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 755
LEU A 758
THR A 779
LEU A 780
 None
 0.84A 4z90A-4ecnA:
undetectable
4z90B-4ecnA:
undetectable
4z90C-4ecnA:
undetectable
4z90D-4ecnA:
undetectable
4z90E-4ecnA:
undetectable		 4z90A-4ecnA:
17.43
4z90B-4ecnA:
17.43
4z90C-4ecnA:
17.43
4z90D-4ecnA:
17.43
4z90E-4ecnA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 779
LEU A 780
THR A 755
LEU A 758
 None
 0.77A 4z90F-4ecnA:
undetectable
4z90G-4ecnA:
undetectable
4z90H-4ecnA:
undetectable
4z90I-4ecnA:
undetectable
4z90J-4ecnA:
undetectable		 4z90F-4ecnA:
17.43
4z90G-4ecnA:
17.43
4z90H-4ecnA:
17.43
4z90I-4ecnA:
17.43
4z90J-4ecnA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 732
ARG A 425
THR A 759
LEU A 758
 None
 0.96A 5b3sA-4ecnA:
undetectable
5b3sJ-4ecnA:
undetectable		 5b3sA-4ecnA:
19.75
5b3sJ-4ecnA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 LYS A 303
ASP A 298
PRO A 368
TYR A 504
 None
 1.36A 5bmvB-4ecnA:
undetectable		 5bmvB-4ecnA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 551
LEU A 628
PHE A 666
PHE A 654
LEU A 616
 None
 1.19A 5fsaA-4ecnA:
undetectable		 5fsaA-4ecnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 382
LEU A 374
GLY A 372
ILE A 468
 None
 0.70A 5ik1A-4ecnA:
undetectable		 5ik1A-4ecnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 677
ASP A 678
LEU A 758
ALA A 703
THR A 759
 None
 1.26A 5nd3B-4ecnA:
undetectable		 5nd3B-4ecnA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 842
VAL A 875
LEU A 839
VAL A 849
ILE A 846
 None
 1.22A 5tuiB-4ecnA:
undetectable		 5tuiB-4ecnA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 810
GLN A 892
ASP A 861
ASP A 434
 None
 1.16A 5vlmE-4ecnA:
undetectable		 5vlmE-4ecnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 732
ARG A 425
THR A 759
LEU A 758
 None
 0.83A 5xdqN-4ecnA:
undetectable
5xdqW-4ecnA:
undetectable		 5xdqN-4ecnA:
19.75
5xdqW-4ecnA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 305
ALA A 301
ALA A 370
GLN A 373
ILE A 465
 None
 1.09A 6a5zD-4ecnA:
undetectable		 6a5zD-4ecnA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 383
ALA A 484
ASP A 523
ILE A 480
LEU A 399
 None
 1.05A 6b3aA-4ecnA:
undetectable		 6b3aA-4ecnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 383
ALA A 484
ASP A 523
ILE A 480
LEU A 399
 None
 1.04A 6b3bA-4ecnA:
undetectable		 6b3bA-4ecnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 448
GLN A 424
ASN A 427
SER A 655
 None
 1.24A 6ekuA-4ecnA:
undetectable		 6ekuA-4ecnA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 383
THR A 462
SER A 357
PHE A 394
 None
 1.00A 6eqpA-4ecnA:
undetectable		 6eqpA-4ecnA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 720
PHE A 654
SER A 655
LEU A 659
ILE A 684
 None
 1.09A 6fdyU-4ecnA:
undetectable		 6fdyU-4ecnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 PRO A 663
PHE A 654
SER A 655
LEU A 659
ILE A 684
 None
 1.10A 6fdyU-4ecnA:
undetectable		 6fdyU-4ecnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ecn LEUCINE-RICH REPEAT
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 732
ARG A 425
THR A 759
LEU A 758
 None
 0.77A 6nmpN-4ecnA:
undetectable
6nmpW-4ecnA:
undetectable		 6nmpN-4ecnA:
19.75
6nmpW-4ecnA:
5.74