SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ecp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		5 / 12 GLY A  53
GLU A  18
TYR A  42
ASP A  57
ASP A  89
 None
None
None
EDO  A 201 (-3.0A)
EDO  A 201 (-3.1A)
 1.31A 2vqyA-4ecpA:
undetectable		 2vqyA-4ecpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
TYR A  38
GLY A  43
ILE A   9
 None
 0.77A 3ihzB-4ecpA:
undetectable		 3ihzB-4ecpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.14A 4feuF-4ecpA:
undetectable		 4feuF-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 7 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.16A 4fevD-4ecpA:
undetectable		 4fevD-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 7 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.14A 4fevF-4ecpA:
undetectable		 4fevF-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.16A 4fewD-4ecpA:
undetectable		 4fewD-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.18A 4fewF-4ecpA:
undetectable		 4fewF-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 7 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.12A 4fexB-4ecpA:
undetectable		 4fexB-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.10A 4gkhB-4ecpA:
undetectable		 4gkhB-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.16A 4gkhF-4ecpA:
undetectable		 4gkhF-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 7 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.17A 4gkhG-4ecpA:
undetectable		 4gkhG-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  57
GLU A  18
ASP A  52
 None
EDO  A 201 (-3.0A)
None
EDO  A 201 (-3.6A)
 1.11A 4gkhC-4ecpA:
undetectable
4gkhK-4ecpA:
undetectable		 4gkhC-4ecpA:
21.05
4gkhK-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.15A 4gkhC-4ecpA:
undetectable
4gkhK-4ecpA:
undetectable		 4gkhC-4ecpA:
21.05
4gkhK-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.17A 4gkiA-4ecpA:
undetectable		 4gkiA-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  89
GLU A 130
GLU A  18
 None
EDO  A 201 (-3.1A)
None
None
 1.13A 4gkiC-4ecpA:
undetectable		 4gkiC-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 8 ASP A  29
ASP A  57
GLU A  18
ASP A  52
 None
EDO  A 201 (-3.0A)
None
EDO  A 201 (-3.6A)
 1.15A 4gkiE-4ecpA:
undetectable
4gkiG-4ecpA:
undetectable		 4gkiE-4ecpA:
21.05
4gkiG-4ecpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		3 / 3 TYR A 126
ARG A  30
LYS A 127
 None
 1.39A 4wq5B-4ecpA:
undetectable		 4wq5B-4ecpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		5 / 12 ASP A  20
PRO A  55
GLY A  43
GLU A   8
TYR A  42
 None
 1.19A 5hfjD-4ecpA:
undetectable		 5hfjD-4ecpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4ecp INORGANIC
PYROPHOSPHATASE
(Mycobacterium
leprae) 		4 / 5 TYR A  38
LYS A  16
GLU A   8
GLY A  43
 None
 1.21A 5jhdJ-4ecpA:
undetectable		 5jhdJ-4ecpA:
21.12