SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4edp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C49_D_HCYD1384_1 (CORTICOSTEROID-BINDI NG GLOBULIN)	4edp	ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Clostridium perfringens)	5 / 12	SER A 37 VAL A 36 GLN A 289 THR A 292 ILE A 264	None None None ACT A 403 (-3.5A) None	1.28A	4c49D-4edpA: undetectable	4c49D-4edpA: 24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FVQ_A_ACTA904_0 (TYROSINE-PROTEIN KINASE JAK2)	4edp	ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Clostridium perfringens)	3 / 3	PHE A 329 VAL A 332 GLU A 180	CL A 401 ( 4.5A) None ACT A 405 (-2.8A)	0.84A	4fvqA-4edpA: undetectable	4fvqA-4edpA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERS_A_ACTA803_0 (GEPHYRIN)	4edp	ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Clostridium perfringens)	3 / 3	THR A 263 ALA A 94 ASN A 265	None	0.50A	5ersA-4edpA: undetectable	5ersA-4edpA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A210_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	4edp	ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Clostridium perfringens)	5 / 12	LEU A 156 VAL A 209 LEU A 202 TYR A 258 GLY A 175	None	1.47A	5i8fA-4edpA: undetectable	5i8fA-4edpA: 19.88

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4C49_D_HCYD1384_1","CORTICOSTEROID-BINDING GLOBULIN","4edp","ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Clostridium perfringens",5,"SER A  37;VAL A  36;GLN A 289;THR A 292;ILE A 264","None;None;None;ACT A 403 (-3.5A);None","1.28A","4c49D-4edpA:undetectable","4c49D-4edpA:24.69"],["4FVQ_A_ACTA904_0","TYROSINE-PROTEIN KINASE JAK2","4edp","ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Clostridium perfringens",3,"PHE A 329;VAL A 332;GLU A 180"," CL A 401 ( 4.5A);None;ACT A 405 (-2.8A)","0.84A","4fvqA-4edpA:undetectable","4fvqA-4edpA:21.43"],["5ERS_A_ACTA803_0","GEPHYRIN","4edp","ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Clostridium perfringens",3,"THR A 263;ALA A  94;ASN A 265","None","0.50A","5ersA-4edpA:undetectable","5ersA-4edpA:20.49"],["5I8F_A_ML1A210_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","4edp","ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Clostridium perfringens",5,"LEU A 156;VAL A 209;LEU A 202;TYR A 258;GLY A 175","None","1.47A","5i8fA-4edpA:undetectable","5i8fA-4edpA:19.88"]]