SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4edq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A  86
PRO A  82
LEU A  90
LEU A 291
LEU A 285
 None
 1.33A 1e7wA-4edqA:
undetectable		 1e7wA-4edqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		3 / 3 GLU A 112
TRP A 231
LYS A 274
 MLR  A 500 (-2.2A)
MLR  A 500 (-4.2A)
None
 1.20A 1qu2A-4edqA:
undetectable		 1qu2A-4edqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 10 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
MLR  A 500 (-3.0A)
None
 1.25A 1wopA-4edqA:
undetectable		 1wopA-4edqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.11A 2f16H-4edqA:
undetectable
2f16I-4edqA:
undetectable		 2f16H-4edqA:
19.33
2f16I-4edqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.10A 2f16V-4edqA:
undetectable
2f16W-4edqA:
undetectable		 2f16V-4edqA:
19.33
2f16W-4edqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.03A 2h42C-4edqA:
undetectable		 2h42C-4edqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 6 ASP A 198
THR A 194
LYS A 201
ASP A 359
 None
 1.25A 2j2pE-4edqA:
undetectable
2j2pF-4edqA:
undetectable		 2j2pE-4edqA:
16.90
2j2pF-4edqA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 8 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MLR  A 500 (-2.2A)
 1.02A 2zw9A-4edqA:
undetectable		 2zw9A-4edqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
 1.23A 3a35A-4edqA:
undetectable		 3a35A-4edqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 6 ALA A 189
LEU A 193
ALA A 347
THR A 346
 None
 0.91A 3b6hA-4edqA:
undetectable		 3b6hA-4edqA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.65A 3bjwC-4edqA:
undetectable		 3bjwC-4edqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.88A 3bjwA-4edqA:
undetectable		 3bjwA-4edqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		4 / 6 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.33A 3gv1A-4edqA:
undetectable
3gv1B-4edqA:
undetectable		 3gv1A-4edqA:
13.01
3gv1B-4edqA:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		12 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
PRO A 155
TRP A 231
TYR A 342
 MLR  A 500 (-1.9A)
MLR  A 500 (-2.7A)
None
MLR  A 500 (-2.6A)
MLR  A 500 (-3.4A)
MLR  A 500 (-2.8A)
MLR  A 500 (-2.1A)
MLR  A 500 (-3.6A)
MLR  A 500 (-2.2A)
MLR  A 500 (-3.0A)
MLR  A 500 (-4.2A)
MLR  A 500 (-3.7A)
 0.23A 3jyrA-4edqA:
60.8		 3jyrA-4edqA:
71.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 MLR  A 500 (-4.6A)
MLR  A 500 (-4.2A)
MLR  A 500 (-3.0A)
MLR  A 500 (-2.9A)
MLR  A 500 ( 3.5A)
MLR  A 500 (-2.9A)
 0.22A 3jyrA-4edqA:
60.8		 3jyrA-4edqA:
71.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.15A 3mg0V-4edqA:
undetectable
3mg0W-4edqA:
undetectable		 3mg0V-4edqA:
19.33
3mg0W-4edqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4edqA:
undetectable		 3n8yB-4edqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 9 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
 None
 1.08A 3ozvB-4edqA:
undetectable		 3ozvB-4edqA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 9 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.17A 3sj4X-4edqA:
undetectable		 3sj4X-4edqA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 500 (-4.0A)
None
None
MLR  A 500 (-2.2A)
None
 0.86A 3tbgB-4edqA:
undetectable		 3tbgB-4edqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MLR  A 500 (-4.0A)
None
None
MLR  A 500 (-2.2A)
None
 0.85A 3tbgD-4edqA:
undetectable		 3tbgD-4edqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.48A 3vwqA-4edqA:
undetectable		 3vwqA-4edqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 12 ILE A 267
ALA A 106
LEU A  21
VAL A  24
ILE A  60
 None
 1.10A 4m2xG-4edqA:
undetectable		 4m2xG-4edqA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-4edqA:
undetectable		 4or0B-4edqA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MLR  A 500 (-2.9A)
None
None
 0.79A 6b58A-4edqA:
undetectable		 6b58A-4edqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN
(Escherichia
coli;
Mus
musculus) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-4edqA:
undetectable		 6bm5A-4edqA:
23.01