SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ee1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		5 / 11 LEU A 264
LEU A 307
GLY A 323
LEU A 290
LEU A 331
 None
 1.21A 3ndvA-4ee1A:
undetectable
3ndvB-4ee1A:
undetectable		 3ndvA-4ee1A:
22.60
3ndvB-4ee1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		5 / 11 GLY A 323
LEU A 290
LEU A 331
LEU A 264
LEU A 307
 None
 1.21A 3ndvC-4ee1A:
undetectable
3ndvD-4ee1A:
undetectable		 3ndvC-4ee1A:
22.60
3ndvD-4ee1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		5 / 12 LEU A 245
VAL A 283
ARG A 156
HIS A 294
THR A 288
 None
 1.36A 4okbA-4ee1A:
undetectable		 4okbA-4ee1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		3 / 3 THR A 149
ASP A 150
ALA A 151
 None
 0.00A 5g5gB-4ee1A:
undetectable		 5g5gB-4ee1A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		4 / 6 ARG A 146
ASP A 270
GLY A 267
ASP A 343
 CTP  A 501 (-2.9A)
CTP  A 501 ( 3.9A)
CTP  A 501 (-3.0A)
MN  A 504 (-2.7A)
 1.19A 5hp1C-4ee1A:
undetectable		 5hp1C-4ee1A:
20.04