SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ee8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 7 GLY A  90
ALA A  74
THR A  82
THR A 118
 None
 0.88A 1gtfL-4ee8A:
undetectable
1gtfM-4ee8A:
undetectable		 1gtfL-4ee8A:
15.19
1gtfM-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 8 GLY A  90
ALA A  74
THR A  82
THR A 118
 None
 0.87A 1gtfN-4ee8A:
undetectable
1gtfO-4ee8A:
undetectable		 1gtfN-4ee8A:
15.19
1gtfO-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 7 LEU A 298
VAL A 218
TYR A 174
GLY A 176
 None
None
SO4  A 401 (-4.6A)
None
 0.87A 1lweA-4ee8A:
undetectable		 1lweA-4ee8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		6 / 11 LEU A 256
ASP A  57
VAL A  23
GLY A 110
THR A  17
VAL A  21
 None
 1.26A 1t7jA-4ee8A:
undetectable		 1t7jA-4ee8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 11 ASP A 165
ASP A  60
GLY A 113
THR A  82
PRO A  83
 None
 0.95A 2nnpA-4ee8A:
undetectable		 2nnpA-4ee8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 5 SER A 286
TYR A 262
VAL A  21
TYR A 269
 None
 0.98A 2x7hA-4ee8A:
undetectable		 2x7hA-4ee8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 5 SER A 286
TYR A 262
VAL A  21
TYR A 269
 None
 0.97A 2x7hB-4ee8A:
undetectable		 2x7hB-4ee8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 7 PRO A  88
ILE A 164
PRO A 137
TRP A 225
 None
 1.00A 2y7kA-4ee8A:
undetectable		 2y7kA-4ee8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 9 LEU A 133
VAL A 130
VAL A 221
ILE A 155
LEU A 223
 None
 0.89A 3cs9B-4ee8A:
undetectable		 3cs9B-4ee8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 8 SER A  44
ASP A   6
LEU A   7
ASP A  39
 None
 1.25A 3n2oC-4ee8A:
undetectable
3n2oD-4ee8A:
undetectable		 3n2oC-4ee8A:
19.50
3n2oD-4ee8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		3 / 3 TYR A 281
ARG A  49
LYS A 283
 SO4  A 402 (-4.5A)
SO4  A 402 ( 3.1A)
SO4  A 401 ( 2.3A)
 1.35A 4wq5B-4ee8A:
undetectable		 4wq5B-4ee8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 8 THR A 118
GLY A  90
ALA A  74
THR A  82
 None
 0.87A 5eezL-4ee8A:
undetectable
5eezV-4ee8A:
undetectable		 5eezL-4ee8A:
15.19
5eezV-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 8 THR A 118
GLY A  90
ALA A  74
THR A  82
 None
 0.87A 5ef1L-4ee8A:
undetectable
5ef1V-4ee8A:
undetectable		 5ef1L-4ee8A:
15.19
5ef1V-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 8 THR A 118
GLY A  90
ALA A  74
THR A  82
 None
 0.87A 5ef2L-4ee8A:
undetectable
5ef2V-4ee8A:
undetectable		 5ef2L-4ee8A:
15.19
5ef2V-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 6 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.30A 5igyA-4ee8A:
undetectable		 5igyA-4ee8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		4 / 6 TYR A 281
ASP A  60
ILE A 284
TYR A 174
 SO4  A 402 (-4.5A)
None
None
SO4  A 401 (-4.6A)
 1.25A 5ih0A-4ee8A:
undetectable		 5ih0A-4ee8A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 10 PHE A 150
ILE A 155
ILE A 219
VAL A 221
PHE A 233
 None
 1.08A 5nukA-4ee8A:
undetectable		 5nukA-4ee8A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 12 THR A  64
VAL A  45
SER A  47
VAL A 270
THR A 234
 None
 1.25A 5v1tA-4ee8A:
undetectable		 5v1tA-4ee8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 12 GLY A 192
ALA A 195
PHE A 233
SER A 216
VAL A 221
 None
 0.99A 6bqgA-4ee8A:
undetectable		 6bqgA-4ee8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4ee8 PRENYLTRANSFERASE
(Streptomyces
cinnamonensis) 		5 / 12 VAL A 187
GLY A 192
ALA A 195
PHE A 233
VAL A 221
 None
 1.16A 6bqgA-4ee8A:
undetectable		 6bqgA-4ee8A:
15.10