SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ee9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 6 GLN A 149
ASP A 153
VAL A 155
GLY A 151
 None
 1.23A 1ekjC-4ee9A:
undetectable
1ekjD-4ee9A:
undetectable		 1ekjC-4ee9A:
22.09
1ekjD-4ee9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 6 ASP A 153
VAL A 155
GLY A 151
GLN A 149
 None
 1.22A 1ekjC-4ee9A:
undetectable
1ekjD-4ee9A:
undetectable		 1ekjC-4ee9A:
22.09
1ekjD-4ee9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ILE A 243
ALA A 198
TRP A 233
LEU A 184
PHE A 196
 None
 1.24A 1g5yB-4ee9A:
undetectable		 1g5yB-4ee9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 8 LEU A 263
TYR A 275
GLY A   6
LEU A 302
TYR A 306
 None
 1.35A 1jlbA-4ee9A:
undetectable		 1jlbA-4ee9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ILE A 132
LEU A 165
ALA A 148
GLY A 168
SER A 172
 None
 1.28A 2a58A-4ee9A:
undetectable
2a58B-4ee9A:
undetectable		 2a58A-4ee9A:
23.87
2a58B-4ee9A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ILE A 132
LEU A 165
ALA A 148
GLY A 168
SER A 172
 None
 1.28A 2a58B-4ee9A:
undetectable
2a58C-4ee9A:
undetectable		 2a58B-4ee9A:
23.87
2a58C-4ee9A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ILE A 132
LEU A 165
ALA A 148
GLY A 168
SER A 172
 None
 1.27A 2a58D-4ee9A:
undetectable
2a58E-4ee9A:
undetectable		 2a58D-4ee9A:
23.87
2a58E-4ee9A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 5 ILE A 166
LEU A 164
ASP A 153
ALA A 148
 None
 0.93A 2opxA-4ee9A:
undetectable		 2opxA-4ee9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ASN A 134
GLU A 135
HIS A 199
GLU A 245
TRP A 276
 TRS  A 401 (-3.0A)
TRS  A 401 (-2.9A)
None
TRS  A 401 (-2.8A)
TRS  A 401 (-3.8A)
 0.52A 2v3dA-4ee9A:
18.8		 2v3dA-4ee9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 VAL A   9
GLY A  11
ALA A  12
LEU A  50
 None
 0.88A 2wekB-4ee9A:
undetectable		 2wekB-4ee9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 12 ILE A 117
ASN A   8
LEU A  55
ALA A  68
LEU A  75
 None
 1.08A 3a50A-4ee9A:
undetectable		 3a50A-4ee9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 LEU A 302
TRP A 255
TYR A 275
 None
 0.96A 3aicB-4ee9A:
4.6		 3aicB-4ee9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 LEU A 302
TRP A 255
TYR A 275
 None
 0.98A 3aicE-4ee9A:
4.7		 3aicE-4ee9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 LEU A 302
TRP A 255
TYR A 275
 None
 1.00A 3aicG-4ee9A:
5.1		 3aicG-4ee9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 LEU A 302
TRP A 255
TYR A 275
 None
 0.98A 3aicH-4ee9A:
4.7		 3aicH-4ee9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 8 TRP A 282
TRP A  38
ARG A 297
ILE A   7
 None
 1.29A 3e7gC-4ee9A:
undetectable
3e7gD-4ee9A:
undetectable		 3e7gC-4ee9A:
22.35
3e7gD-4ee9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 ARG A 297
ILE A   7
TRP A 282
TRP A  38
 None
 1.40A 3ej8A-4ee9A:
undetectable
3ej8B-4ee9A:
undetectable		 3ej8A-4ee9A:
22.35
3ej8B-4ee9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 TRP A 282
TRP A  38
ARG A 297
ILE A   7
 None
 1.41A 3ej8A-4ee9A:
undetectable
3ej8B-4ee9A:
undetectable		 3ej8A-4ee9A:
22.35
3ej8B-4ee9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 ARG A 297
ILE A   7
TRP A 282
TRP A  38
 None
 1.39A 3ej8C-4ee9A:
undetectable
3ej8D-4ee9A:
undetectable		 3ej8C-4ee9A:
22.35
3ej8D-4ee9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 TRP A 282
TRP A  38
ARG A 297
ILE A   7
 None
 1.38A 3ej8C-4ee9A:
undetectable
3ej8D-4ee9A:
undetectable		 3ej8C-4ee9A:
22.35
3ej8D-4ee9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 ASN A   8
ASP A 131
ARG A 176
 None
 0.85A 3k13A-4ee9A:
10.4		 3k13A-4ee9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 GLU A 253
LEU A 256
ASP A 257
 None
 0.30A 3ko0A-4ee9A:
undetectable		 3ko0A-4ee9A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 10 GLY A 238
ILE A 166
PHE A 128
GLY A 316
PHE A 315
 None
 1.35A 3ko0R-4ee9A:
undetectable
3ko0T-4ee9A:
undetectable		 3ko0R-4ee9A:
12.81
3ko0T-4ee9A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 GLU A 253
LEU A 256
ASP A 257
 None
 0.34A 3ko0T-4ee9A:
undetectable		 3ko0T-4ee9A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		5 / 11 GLU A 135
GLY A 168
ILE A 166
GLU A 167
ALA A 148
 TRS  A 401 (-2.9A)
None
None
None
None
 1.14A 3nmuB-4ee9A:
undetectable
3nmuJ-4ee9A:
undetectable		 3nmuB-4ee9A:
23.97
3nmuJ-4ee9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 5 VAL A   2
GLU A 321
LYS A 240
PHE A 315
 None
 1.39A 3rv5C-4ee9A:
undetectable
3rv5D-4ee9A:
undetectable		 3rv5C-4ee9A:
13.42
3rv5D-4ee9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		3 / 3 ASN A   8
TRP A 276
ASP A 131
 None
TRS  A 401 (-3.8A)
None
 1.26A 4a7tA-4ee9A:
undetectable
4a7tF-4ee9A:
undetectable		 4a7tA-4ee9A:
18.91
4a7tF-4ee9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 260
ASP A 257
ASN A 267
GLU A 268
 None
None
TRS  A 402 (-3.0A)
None
 1.02A 4feuD-4ee9A:
0.6		 4feuD-4ee9A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 8 ILE A  83
ILE A  86
PHE A  48
GLY A  11
 None
 0.98A 4hdlA-4ee9A:
undetectable		 4hdlA-4ee9A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 GLU A 135
GLY A 208
GLY A 247
ALA A 206
 TRS  A 401 (-2.9A)
None
None
None
 0.88A 5e26A-4ee9A:
undetectable
5e26B-4ee9A:
undetectable		 5e26A-4ee9A:
22.96
5e26B-4ee9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 ALA A 206
GLU A 135
GLY A 208
GLY A 247
 None
TRS  A 401 (-2.9A)
None
None
 0.88A 5e26A-4ee9A:
undetectable
5e26B-4ee9A:
undetectable		 5e26A-4ee9A:
22.96
5e26B-4ee9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 7 GLU A 135
GLY A 208
GLY A 247
ALA A 206
 TRS  A 401 (-2.9A)
None
None
None
 0.86A 5e26C-4ee9A:
undetectable
5e26D-4ee9A:
undetectable		 5e26C-4ee9A:
22.96
5e26D-4ee9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4ee9 ENDOGLUCANASE
(uncultured
bacterium) 		4 / 8 ALA A 206
GLU A 135
GLY A 208
GLY A 247
 None
TRS  A 401 (-2.9A)
None
None
 0.86A 5e26C-4ee9A:
undetectable
5e26D-4ee9A:
undetectable		 5e26C-4ee9A:
22.96
5e26D-4ee9A:
22.96