SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4eec STAL
(Streptomyces
toyocaensis) 		5 / 12 ALA A 263
GLY A 267
LEU A 252
ALA A 260
PRO A 139
 None
 1.14A 1mjqC-4eecA:
undetectable
1mjqD-4eecA:
undetectable		 1mjqC-4eecA:
17.63
1mjqD-4eecA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4eec STAL
(Streptomyces
toyocaensis) 		5 / 12 ALA A 263
GLY A 267
LEU A 252
ALA A 260
PRO A 139
 None
 1.13A 1mjqI-4eecA:
undetectable
1mjqJ-4eecA:
undetectable		 1mjqI-4eecA:
17.63
1mjqJ-4eecA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4eec STAL
(Streptomyces
toyocaensis) 		4 / 5 ILE A 105
PRO A 106
PHE A 240
VAL A 110
 None
 1.09A 2hjhB-4eecA:
1.9		 2hjhB-4eecA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4eec STAL
(Streptomyces
toyocaensis) 		4 / 6 PRO A 170
LEU A 174
ARG A 167
GLY A  14
 None
None
None
A3P  A 301 (-3.4A)
 1.22A 2hs2B-4eecA:
undetectable		 2hs2B-4eecA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 4eec STAL
(Streptomyces
toyocaensis) 		4 / 8 LEU A 166
VAL A  86
LEU A  88
ILE A   7
 None
 0.79A 6cb4A-4eecA:
undetectable		 6cb4A-4eecA:
20.35