SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.62A 1cqeA-4eelA:
undetectable		 1cqeA-4eelA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.63A 1cqeB-4eelA:
undetectable		 1cqeB-4eelA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 ASP A  12
VAL A 168
GLY A 175
GLY A 176
 CIT  A 301 ( 2.7A)
None
CIT  A 301 ( 4.3A)
None
 0.74A 1ekjE-4eelA:
undetectable
1ekjF-4eelA:
undetectable		 1ekjE-4eelA:
23.60
1ekjF-4eelA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LEU A  32
TRP A  28
LEU A  76
PHE A  53
 None
 1.47A 1ru9H-4eelA:
undetectable
1ru9L-4eelA:
undetectable		 1ru9H-4eelA:
20.22
1ru9L-4eelA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 LYS A 146
THR A  88
SER A 113
GLU A 170
 CIT  A 301 (-2.8A)
None
CIT  A 301 (-3.3A)
CIT  A 301 ( 4.5A)
 1.30A 1xr2B-4eelA:
undetectable		 1xr2B-4eelA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.65A 2aylB-4eelA:
undetectable		 2aylB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 VAL A   9
VAL A 167
LEU A 218
TRP A 187
 None
 0.87A 2gehA-4eelA:
undetectable		 2gehA-4eelA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 9 GLY A 175
SER A 172
ASP A 171
ASP A  12
GLU A  21
 CIT  A 301 ( 4.3A)
CIT  A 301 ( 4.2A)
NA  A 302 (-2.8A)
CIT  A 301 ( 2.7A)
None
 1.49A 2j2pB-4eelA:
undetectable
2j2pC-4eelA:
undetectable		 2j2pB-4eelA:
22.26
2j2pC-4eelA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A  32
LEU A  60
GLU A  77
PHE A  80
PHE A  48
 None
 1.19A 2weyA-4eelA:
undetectable		 2weyA-4eelA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 VAL A   9
ILE A 169
VAL A 167
LEU A 218
TRP A 187
 None
 0.95A 3fw3A-4eelA:
undetectable		 3fw3A-4eelA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 VAL A   9
ILE A 169
VAL A 167
LEU A 218
TRP A 187
 None
 0.98A 3fw3B-4eelA:
undetectable		 3fw3B-4eelA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 SER A  20
SER A 111
LEU A  13
ASP A  12
 None
CIT  A 301 (-2.6A)
CIT  A 301 (-4.2A)
CIT  A 301 ( 2.7A)
 0.98A 3lsfH-4eelA:
undetectable		 3lsfH-4eelA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A 102
ALA A  99
PHE A   6
THR A 229
LEU A 228
 None
 0.96A 3mteB-4eelA:
undetectable		 3mteB-4eelA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.81A 3n8xA-4eelA:
undetectable		 3n8xA-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.67A 3n8xB-4eelA:
undetectable		 3n8xB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.64A 3n8yA-4eelA:
undetectable		 3n8yA-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		6 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
LEU A 100
 None
 0.66A 3n8yB-4eelA:
undetectable		 3n8yB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 VAL A   9
ILE A  90
ALA A  93
LEU A  97
LEU A 100
 None
 0.87A 3n8yB-4eelA:
undetectable		 3n8yB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.64A 3n8zB-4eelA:
undetectable		 3n8zB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 TYR A 152
LEU A 151
ARG A 144
PRO A 138
GLY A 110
 None
 1.33A 3okxB-4eelA:
undetectable		 3okxB-4eelA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A 102
ALA A  99
PHE A   6
THR A 229
LEU A 228
 None
 0.96A 3p2kA-4eelA:
undetectable		 3p2kA-4eelA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY A 179
GLY A 176
GLY A 175
LEU A  10
ALA A 184
 None
None
CIT  A 301 ( 4.3A)
None
None
 1.01A 4htfB-4eelA:
2.4		 4htfB-4eelA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 LEU A 151
TYR A 152
VAL A 141
LEU A 118
 None
 0.82A 4l1xA-4eelA:
undetectable		 4l1xA-4eelA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  27
ALA A  25
GLY A  86
SER A  20
GLY A  22
 None
 1.29A 4mmbA-4eelA:
undetectable		 4mmbA-4eelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  27
ALA A  25
GLY A  86
SER A  20
GLY A  22
 None
 1.29A 4mmeA-4eelA:
undetectable		 4mmeA-4eelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ALA A 225
ARG A 210
VAL A  16
LEU A 218
LEU A 100
 None
 1.36A 4qzuA-4eelA:
undetectable		 4qzuA-4eelA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		6 / 12 TYR A 152
GLY A 110
GLY A 179
LEU A 180
GLY A  15
VAL A  16
 None
None
None
None
NA  A 302 ( 4.7A)
None
 1.25A 5i73A-4eelA:
undetectable		 5i73A-4eelA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 8 VAL A   9
VAL A 167
LEU A 218
TRP A 187
 None
 0.82A 5tt3F-4eelA:
undetectable		 5tt3F-4eelA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		3 / 3 GLY A 126
THR A 128
GLU A 129
 None
 0.63A 6b58A-4eelA:
undetectable		 6b58A-4eelA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN
(Deinococcus
radiodurans) 		4 / 5 HIS A  38
GLU A  43
LEU A  57
VAL A  56
 None
 1.07A 6bc9A-4eelA:
undetectable		 6bc9A-4eelA:
14.80