SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ees'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 11 LEU A 472
THR A 453
ILE A 393
THR A 394
VAL A 392
 FMN  A1001 (-4.8A)
None
None
FMN  A1001 (-3.3A)
None
 1.19A 1pkvA-4eesA:
undetectable
1pkvB-4eesA:
undetectable		 1pkvA-4eesA:
22.90
1pkvB-4eesA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 11 VAL A 392
LEU A 472
THR A 453
ILE A 393
THR A 394
 None
FMN  A1001 (-4.8A)
None
None
FMN  A1001 (-3.3A)
 1.23A 1pkvA-4eesA:
undetectable
1pkvB-4eesA:
undetectable		 1pkvA-4eesA:
22.90
1pkvB-4eesA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.33A 3elzA-4eesA:
undetectable		 3elzA-4eesA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 11 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.25A 3elzB-4eesA:
1.7		 3elzB-4eesA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 THR A 453
VAL A 454
VAL A 475
ILE A 486
THR A 394
 None
None
None
None
FMN  A1001 (-3.3A)
 1.37A 3elzC-4eesA:
undetectable		 3elzC-4eesA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 VAL A 392
ASN A 401
ASN A 425
ARG A 427
GLN A 430
ASN A 458
ASN A 468
LEU A 470
GLN A 489
 None
FMN  A1001 (-3.8A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.9A)
 0.32A 4kukA-4eesA:
20.2		 4kukA-4eesA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 9 LEU A 429
VAL A 439
ILE A 442
PHE A 485
GLY A 487
 FMN  A1001 (-4.2A)
FMN  A1001 (-4.5A)
FMN  A1001 (-4.1A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.8A)
 0.26A 4kukA-4eesA:
20.2		 4kukA-4eesA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 VAL A 392
ASN A 401
ASN A 425
ARG A 427
GLN A 430
ASN A 458
ASN A 468
LEU A 470
GLN A 489
 None
FMN  A1001 (-3.8A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.9A)
 0.49A 4kuoA-4eesA:
20.1		 4kuoA-4eesA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.55A 4r38A-4eesA:
7.6		 4r38A-4eesA:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		4 / 8 ASN A 425
LEU A 429
VAL A 439
PHE A 485
 FMN  A1001 (-3.0A)
FMN  A1001 (-4.2A)
FMN  A1001 (-4.5A)
FMN  A1001 (-4.6A)
 0.60A 4r38A-4eesA:
7.6		 4r38A-4eesA:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 ASN A 425
ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.0A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.56A 4r38B-4eesA:
19.6		 4r38B-4eesA:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.54A 4r38C-4eesA:
19.7		 4r38C-4eesA:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.54A 4r38D-4eesA:
19.8		 4r38D-4eesA:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		7 / 12 ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLN A 489
 FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.9A)
 0.47A 4r3aA-4eesA:
15.7		 4r3aA-4eesA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		7 / 12 ARG A 427
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.8A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.44A 4r3aB-4eesA:
15.8		 4r3aB-4eesA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ees PHOTOTROPIN-2
(Arabidopsis
thaliana) 		4 / 7 LEU A 470
THR A 452
LEU A 472
THR A 438
 FMN  A1001 (-4.2A)
None
FMN  A1001 (-4.8A)
None
 0.93A 4z90A-4eesA:
undetectable
4z90B-4eesA:
undetectable
4z90C-4eesA:
undetectable
4z90D-4eesA:
undetectable
4z90E-4eesA:
undetectable		 4z90A-4eesA:
18.30
4z90B-4eesA:
18.30
4z90C-4eesA:
18.30
4z90D-4eesA:
18.30
4z90E-4eesA:
18.30