SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		3 / 3 VAL A 288
VAL A 262
TRP A  86
 None
 0.97A 1bdwA-4eexA:
undetectable
1bdwB-4eexA:
undetectable		 1bdwA-4eexA:
3.42
1bdwB-4eexA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 LEU A 178
ASN A 177
LEU A 175
GLY A 174
ILE A 207
 None
 1.04A 1p93A-4eexA:
undetectable		 1p93A-4eexA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 11 SER A 144
GLY A  37
VAL A  38
SER A 143
ILE A 336
 None
 0.85A 1pk9C-4eexA:
undetectable		 1pk9C-4eexA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 LEU A  58
LEU A  43
MET A 325
CYH A 147
THR A 146
 None
None
None
ZN  A 402 (-2.3A)
None
 1.32A 2aa5A-4eexA:
undetectable		 2aa5A-4eexA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		4 / 8 THR A 103
VAL A 150
THR A 151
VAL A 158
 None
 0.90A 2qbmA-4eexA:
undetectable		 2qbmA-4eexA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		3 / 3 GLU A  61
VAL A  38
CYH A  39
 None
None
ZN  A 402 (-2.2A)
 1.09A 3fbxA-4eexA:
0.5		 3fbxA-4eexA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 9 ALA A 242
ILE A 196
GLY A 171
PRO A 220
ILE A 244
 None
 1.13A 3nuoA-4eexA:
undetectable		 3nuoA-4eexA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 9 ASN A 177
GLY A 174
GLY A 332
ARG A 333
GLY A 173
 None
 1.45A 4h2fA-4eexA:
undetectable		 4h2fA-4eexA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 ILE A 169
CYH A 239
GLY A 173
ILE A 207
ALA A 204
 None
 0.95A 4kicB-4eexA:
undetectable		 4kicB-4eexA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 10 ALA A 172
ILE A 169
VAL A 168
ALA A 245
ALA A 240
 None
 1.05A 4lbgA-4eexA:
4.1		 4lbgA-4eexA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		4 / 6 LEU A  31
GLU A  28
VAL A 115
ALA A 111
 None
 1.00A 4nkxA-4eexA:
undetectable		 4nkxA-4eexA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		4 / 7 MET A 325
HIS A  60
CYH A 147
GLY A  37
 None
ZN  A 402 (-3.2A)
ZN  A 402 (-2.3A)
None
 1.08A 5a5zC-4eexA:
2.2		 5a5zC-4eexA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		3 / 3 ASN A  52
ASP A  11
GLY A  12
 None
 0.66A 5fctB-4eexA:
undetectable		 5fctB-4eexA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		3 / 3 GLY A  92
CYH A  97
CYH A  94
 ZN  A 401 ( 4.8A)
ZN  A 401 (-2.3A)
ZN  A 401 (-2.2A)
 0.94A 5inzB-4eexA:
undetectable		 5inzB-4eexA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 GLU A 331
LEU A 201
GLY A 176
ASN A 177
ALA A 209
 None
 1.42A 5kc4A-4eexA:
undetectable		 5kc4A-4eexA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 9 ALA A 242
ILE A 196
GLY A 171
PRO A 220
ILE A 244
 None
 1.14A 5kr0A-4eexA:
undetectable		 5kr0A-4eexA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		4 / 7 VAL A  66
ILE A  69
VAL A 125
ALA A  29
 None
 0.75A 5osrA-4eexA:
undetectable		 5osrA-4eexA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 GLY A 171
GLY A 173
ILE A 196
GLN A 248
ALA A 240
 None
 0.89A 5x7fA-4eexA:
9.0		 5x7fA-4eexA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		5 / 12 GLY A 216
ILE A 196
ILE A 224
VAL A 168
ILE A 213
 None
 1.01A 6emuA-4eexA:
3.0		 6emuA-4eexA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4eex ALCOHOL
DEHYDROGENASE 1
(Lactococcus
lactis) 		4 / 6 MET A 325
GLY A 332
ALA A 148
LEU A 175
 None
 0.75A 6fosA-4eexA:
undetectable		 6fosA-4eexA:
11.01