SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ef1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		4 / 4 ILE A 107
LEU A  59
VAL A  48
ILE A  44
 None
 0.88A 1fm6D-4ef1A:
undetectable		 1fm6D-4ef1A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		5 / 11 PHE A 205
ALA A 206
LEU A 220
ALA A 219
THR A 188
 None
 0.85A 1jinA-4ef1A:
undetectable		 1jinA-4ef1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A  52
VAL A  48
GLU A  46
ILE A 231
ALA A  81
 None
 1.18A 2gj5A-4ef1A:
undetectable		 2gj5A-4ef1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A 217
LEU A 122
GLN A 123
ILE A 131
TYR A 191
 None
 1.41A 3ia4A-4ef1A:
undetectable		 3ia4A-4ef1A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		5 / 9 ASP A 192
VAL A 199
ALA A 198
TYR A 191
GLY A 196
 None
 1.38A 4mmfA-4ef1A:
undetectable		 4mmfA-4ef1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		3 / 3 THR A  65
PRO A  38
ASP A 208
 None
 0.92A 5l8dB-4ef1A:
3.8		 5l8dB-4ef1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		3 / 3 THR A  65
PRO A  38
ASP A 208
 None
 0.92A 5mwuB-4ef1A:
3.8		 5mwuB-4ef1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY
(Enterococcus
faecalis) 		5 / 10 VAL A  34
ALA A  36
LEU A 246
LEU A 250
LEU A  59
 None
 0.97A 6f5uA-4ef1A:
undetectable
6f5uB-4ef1A:
undetectable		 6f5uA-4ef1A:
18.52
6f5uB-4ef1A:
14.63