SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4efc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 PHE A  58
PHE A 131
PRO A  70
SER A 126
MET A 120
 None
 1.42A 1fm4A-4efcA:
undetectable		 1fm4A-4efcA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLY A 362
SER A 332
HIS A 280
LEU A 343
LEU A 212
 None
 1.47A 1fm6D-4efcA:
1.3		 1fm6D-4efcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLY A 222
PHE A 221
HIS A 231
PHE A 228
TYR A  57
 None
 1.48A 1t69A-4efcA:
undetectable		 1t69A-4efcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 283
LEU A 205
GLY A 164
ASP A 163
ALA A 161
 None
 1.14A 2br4E-4efcA:
undetectable		 2br4E-4efcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 6 SER A 310
GLU A 323
SER A 295
GLN A 292
 EDO  A 503 (-3.0A)
None
None
None
 1.28A 2cl5B-4efcA:
undetectable		 2cl5B-4efcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 ILE A 154
ALA A 153
LEU A 361
LEU A 336
HIS A 280
 None
 1.12A 2h77A-4efcA:
undetectable		 2h77A-4efcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 6 LEU A 136
MET A 148
MET A 149
LEU A 254
 None
 1.44A 2oz7A-4efcA:
undetectable		 2oz7A-4efcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 7 GLY A 135
PHE A 221
ILE A 141
PHE A 247
 None
 1.02A 2qmzA-4efcA:
undetectable
2qmzB-4efcA:
undetectable		 2qmzA-4efcA:
17.72
2qmzB-4efcA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 ARG A  50
LEU A 248
LEU A 252
PHE A 221
ARG A  48
 None
 1.25A 2v0mC-4efcA:
undetectable		 2v0mC-4efcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 6 LEU A 101
SER A  91
PHE A  90
GLU A  97
 None
 1.20A 2vn1B-4efcA:
undetectable		 2vn1B-4efcA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 7 GLN A 257
ILE A 150
TYR A 266
CYH A 273
 None
 1.43A 2xz5D-4efcA:
undetectable
2xz5E-4efcA:
undetectable		 2xz5D-4efcA:
17.08
2xz5E-4efcA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 5 GLN A  33
THR A  34
HIS A 280
LEU A 329
 None
 1.22A 2zj0A-4efcA:
undetectable		 2zj0A-4efcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 ALA A 161
ALA A  36
LEU A 272
LEU A 336
HIS A 280
 None
 1.04A 3b0wB-4efcA:
undetectable		 3b0wB-4efcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 PHE A 247
LEU A  61
ILE A 141
VAL A  74
GLU A 113
 None
 1.12A 3w1wB-4efcA:
undetectable		 3w1wB-4efcA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 9 GLY A 362
ALA A 368
GLY A 366
HIS A 280
CYH A 369
 None
 1.10A 4c5lB-4efcA:
undetectable		 4c5lB-4efcA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 10 GLY A 362
ALA A 368
GLY A 366
HIS A 280
CYH A 369
 None
 1.11A 4c5lC-4efcA:
undetectable		 4c5lC-4efcA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 10 GLY A 362
ALA A 368
GLY A 366
HIS A 280
CYH A 369
 None
 1.06A 4c5nB-4efcA:
undetectable		 4c5nB-4efcA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 10 GLY A 362
ALA A 368
GLY A 366
HIS A 280
CYH A 369
 None
 1.08A 4c5nD-4efcA:
undetectable		 4c5nD-4efcA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLU A 402
VAL A 399
PRO A 191
THR A 192
GLU A 197
 None
 1.40A 4k88A-4efcA:
undetectable		 4k88A-4efcA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 8 SER A 346
ASP A 351
VAL A 357
THR A 356
 None
None
None
AMP  A 501 (-4.5A)
 1.10A 4lnwA-4efcA:
undetectable		 4lnwA-4efcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 8 GLY A  28
THR A  34
TYR A  30
ARG A  29
 None
 1.13A 4m5mA-4efcA:
undetectable		 4m5mA-4efcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 279
ALA A 368
ALA A 161
ALA A 153
ILE A 365
 None
 0.89A 4nkxC-4efcA:
undetectable		 4nkxC-4efcA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 279
ALA A 368
ALA A 161
ALA A 153
ILE A 365
 None
 0.90A 4nkxD-4efcA:
undetectable		 4nkxD-4efcA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		3 / 3 PRO A  25
LEU A  26
GLN A  33
 None
 0.69A 4pevB-4efcA:
undetectable		 4pevB-4efcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 181
GLU A 402
VAL A 399
PRO A 191
THR A 192
 None
 1.35A 4q15B-4efcA:
undetectable		 4q15B-4efcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 4 LEU A 408
VAL A 407
GLU A 411
ARG A 410
 None
 1.23A 4ww7A-4efcA:
undetectable		 4ww7A-4efcA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 5 LEU A 157
PHE A  41
ILE A 154
ILE A 150
 None
 1.07A 5dzk4-4efcA:
undetectable
5dzkg-4efcA:
undetectable
5dzkm-4efcA:
undetectable
5dzkn-4efcA:
undetectable		 5dzk4-4efcA:
0.59
5dzkg-4efcA:
19.79
5dzkm-4efcA:
18.11
5dzkn-4efcA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 5 SER A 310
GLU A 323
SER A 295
GLN A 292
 EDO  A 503 (-3.0A)
None
None
None
 1.30A 5fhrB-4efcA:
undetectable		 5fhrB-4efcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 379
SER A 376
LEU A 173
TRP A 176
LEU A 205
 None
 1.15A 5iktB-4efcA:
undetectable		 5iktB-4efcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 VAL A  65
ALA A  60
THR A 144
GLY A 135
LEU A 136
 None
 1.28A 5m54E-4efcA:
2.3		 5m54E-4efcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLN A 257
LEU A 254
ILE A 146
ARG A  50
HIS A 133
 None
 1.40A 5uh6C-4efcA:
undetectable		 5uh6C-4efcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLN A 257
LEU A 254
ILE A 146
ARG A  50
HIS A 133
 None
 1.36A 5uhcC-4efcA:
1.6		 5uhcC-4efcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 5 VAL A  55
LEU A 125
CYH A 123
ASP A  88
 None
 1.45A 5vcvA-4efcA:
undetectable		 5vcvA-4efcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 PHE A 339
PHE A 372
ALA A 161
ALA A 153
ILE A 150
 None
 1.01A 5veuB-4efcA:
undetectable		 5veuB-4efcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 GLU A 402
VAL A 399
PRO A 191
THR A 192
GLU A 197
 None
 1.27A 5xipD-4efcA:
undetectable		 5xipD-4efcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		5 / 12 LEU A 181
GLU A 402
VAL A 399
PRO A 191
GLU A 197
 None
 1.43A 5xipD-4efcA:
undetectable		 5xipD-4efcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		3 / 3 SER A 332
HIS A 280
TYR A 158
 None
 1.05A 5y2tA-4efcA:
undetectable		 5y2tA-4efcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4efc ADENYLOSUCCINATE
LYASE
(Trypanosoma
brucei) 		4 / 6 ASP A  76
GLN A  78
LEU A 125
PHE A  58
 None
 1.26A 6ekuA-4efcA:
undetectable		 6ekuA-4efcA:
21.54