SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 11 VAL A 299
LEU A 300
ALA A 301
ALA A  75
THR A 290
 None
 0.89A 1jinA-4effA:
undetectable		 1jinA-4effA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 7 LEU A 168
TYR A 151
GLY A 163
TYR A 171
 None
 1.01A 1lweA-4effA:
2.3		 1lweA-4effA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 327
GLY A 188
GLY A 348
ILE A 343
LEU A 363
 None
 1.02A 1p91B-4effA:
undetectable		 1p91B-4effA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 LEU A  84
LEU A  85
SER A  89
 None
 0.69A 1tlmA-4effA:
undetectable		 1tlmA-4effA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A 113
LEU A 277
LEU A 260
ALA A 100
LEU A 109
 None
 0.99A 2bxeA-4effA:
undetectable		 2bxeA-4effA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 ASP A 190
LEU A 191
ALA A 229
ASN A 192
PHE A 161
 None
 1.22A 2ejtA-4effA:
undetectable		 2ejtA-4effA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 9 ALA A  75
ALA A 297
PHE A 246
GLY A 258
SER A  79
 None
 0.99A 2vh3A-4effA:
undetectable		 2vh3A-4effA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A  25
PHE A  22
LEU A  18
 None
 0.51A 2zi9A-4effA:
undetectable		 2zi9A-4effA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 262
ALA A 100
LEU A 260
LEU A 116
ALA A 142
 None
 1.14A 3ozuA-4effA:
undetectable		 3ozuA-4effA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 115
ALA A 100
PHE A 241
THR A 264
 None
 0.99A 3t3sE-4effA:
undetectable		 3t3sE-4effA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.75A 4zdzA-4effA:
undetectable		 4zdzA-4effA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 7 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.82A 4ze3A-4effA:
undetectable		 4ze3A-4effA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 148
VAL A 146
VAL A 199
PHE A 233
TYR A 171
 None
 1.44A 4zj8A-4effA:
2.3		 4zj8A-4effA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.71A 5esfA-4effA:
undetectable		 5esfA-4effA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 342
ILE A 343
GLY A 354
LEU A 398
 None
 0.79A 5esjA-4effA:
undetectable		 5esjA-4effA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 342
LEU A 327
LEU A 331
ALA A 371
LEU A 363
 None
 1.19A 5iepA-4effA:
undetectable		 5iepA-4effA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 317
PHE A 219
GLY A 218
 None
 0.81A 6fgdA-4effA:
2.7		 6fgdA-4effA:
23.31