SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4efh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		4 / 8 SER A 350
THR A 351
GLU A 361
LYS A 373
 None
 1.20A 1mxgA-4efhA:
undetectable		 1mxgA-4efhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 11 ILE A 309
HIS A 275
GLY A 156
LEU A 185
PHE A 306
 None
None
ADP  A 403 (-3.3A)
None
ADP  A 403 (-3.7A)
 1.20A 2azyA-4efhA:
undetectable		 2azyA-4efhA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 12 LEU A 242
ILE A 208
ILE A 212
LEU A 193
THR A 194
 None
 0.93A 2bdmA-4efhA:
undetectable		 2bdmA-4efhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		3 / 3 PRO A  98
THR A 129
PRO A 102
 None
 0.86A 2d55C-4efhA:
undetectable		 2d55C-4efhA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 10 GLU A 270
MET A 269
THR A 160
LEU A 185
LEU A 261
 None
 1.48A 2ha6A-4efhA:
undetectable		 2ha6A-4efhA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 10 GLU A 270
MET A 269
THR A 160
LEU A 185
LEU A 261
 None
 1.48A 2ha6B-4efhA:
undetectable		 2ha6B-4efhA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 12 GLU A 207
ILE A  34
TYR A  69
ASP A 187
MET A 190
 None
 1.37A 2qeoA-4efhA:
undetectable		 2qeoA-4efhA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		3 / 3 HIS A 228
PHE A 223
PHE A 255
 None
 0.77A 3lk0D-4efhA:
undetectable		 3lk0D-4efhA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 12 LEU A 178
LEU A 153
VAL A 297
THR A 278
ASN A 280
 None
 0.87A 3r9cA-4efhA:
undetectable		 3r9cA-4efhA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		3 / 3 PRO A 243
ASP A 244
GLU A 205
 None
 0.80A 3v4tC-4efhA:
undetectable		 3v4tC-4efhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 11 ALA A 135
THR A 129
PHE A  90
ILE A  10
ASN A  12
 None
 1.41A 4bb2A-4efhA:
undetectable
4bb2B-4efhA:
undetectable		 4bb2A-4efhA:
22.33
4bb2B-4efhA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		4 / 7 ALA A 260
PRO A 258
LEU A 180
LEU A 267
 None
 0.82A 4iomA-4efhA:
2.8		 4iomA-4efhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 10 ASP A 154
ALA A 138
GLY A 342
ILE A 341
VAL A 152
 CA  A 401 ( 4.4A)
None
None
None
None
 1.10A 4j5jB-4efhA:
undetectable		 4j5jB-4efhA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		3 / 3 PRO A 109
LEU A 110
HIS A 173
 None
 0.59A 4pevA-4efhA:
undetectable		 4pevA-4efhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 12 SER A 300
GLY A 302
GLY A 301
ALA A 138
GLN A 137
 None
ADP  A 403 (-3.3A)
ADP  A 403 (-3.5A)
None
CA  A 401 ( 4.3A)
 1.26A 4ubeA-4efhA:
undetectable		 4ubeA-4efhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		4 / 6 LYS A 336
ASP A 154
TYR A 337
PRO A  27
 ADP  A 403 (-3.6A)
CA  A 401 ( 4.4A)
None
None
 1.38A 5bmvB-4efhA:
undetectable		 5bmvB-4efhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		4 / 5 GLU A  93
ASP A  56
VAL A  30
ALA A  29
 None
 1.46A 5dl9A-4efhA:
undetectable		 5dl9A-4efhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		3 / 3 GLN A 137
THR A 106
ASP A  11
 CA  A 401 ( 4.3A)
None
CA  A 401 ( 4.2A)
 0.92A 5k9dA-4efhA:
undetectable		 5k9dA-4efhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4efh ACTIN-1
(Acanthamoeba
castellanii) 		5 / 10 PHE A 306
SER A 155
GLY A 302
PHE A 262
ILE A 274
 ADP  A 403 (-3.7A)
None
ADP  A 403 (-3.3A)
None
None
 1.19A 6ebpC-4efhA:
undetectable		 6ebpC-4efhA:
12.77