SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4efi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  21
GLY A  83
GLY A  85
TRP A  86
LEU A 322
 None
 0.99A 1eizA-4efiA:
undetectable		 1eizA-4efiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		6 / 11 ALA A 341
ALA A 343
VAL A 347
LEU A 322
MET A 331
TYR A 134
 None
 0.91A 1rlbF-4efiA:
undetectable		 1rlbF-4efiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		6 / 11 LEU A 345
ALA A 341
VAL A 347
LEU A 322
MET A 331
TYR A 134
 None
 1.26A 1rlbF-4efiA:
undetectable		 1rlbF-4efiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 137
LEU A 138
LEU A 155
LEU A  94
GLY A 180
 None
 1.01A 2jfaB-4efiA:
undetectable		 2jfaB-4efiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  21
ALA A  76
ILE A 356
LEU A 312
ILE A 314
 None
 1.29A 3adsB-4efiA:
undetectable		 3adsB-4efiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		3 / 3 THR A 358
SER A  68
LYS A 163
 None
 1.16A 3aocC-4efiA:
undetectable		 3aocC-4efiA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  21
GLY A  83
GLY A  85
TRP A  86
LEU A 322
 None
 0.97A 3douA-4efiA:
undetectable		 3douA-4efiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 ILE A 241
GLY A 238
SER A 171
ASN A 276
 None
 0.85A 3lslA-4efiA:
undetectable
3lslD-4efiA:
undetectable		 3lslA-4efiA:
22.46
3lslD-4efiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 171
ASN A 276
ILE A 241
GLY A 238
 None
 0.82A 3lslA-4efiA:
undetectable
3lslD-4efiA:
undetectable		 3lslA-4efiA:
22.46
3lslD-4efiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 7 GLY A 228
ALA A 227
ALA A 220
ASP A 223
 None
 0.88A 3ur0B-4efiA:
undetectable		 3ur0B-4efiA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 6 CYH A 307
GLY A 158
ASP A 159
ILE A 161
 None
 0.99A 3w9tF-4efiA:
undetectable		 3w9tF-4efiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 ASN A 298
SER A  24
ARG A  61
GLU A 317
THR A 305
 None
 1.49A 4xt7A-4efiA:
undetectable		 4xt7A-4efiA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 4 VAL A 210
ILE A 161
ASN A 128
VAL A 336
 None
None
None
UNL  A 401 ( 4.9A)
 1.26A 5ajqA-4efiA:
undetectable		 5ajqA-4efiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5eeyO-4efiA:
undetectable
5eeyP-4efiA:
undetectable		 5eeyO-4efiA:
11.27
5eeyP-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5eezO-4efiA:
undetectable
5eezP-4efiA:
undetectable		 5eezO-4efiA:
11.27
5eezP-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5ef0O-4efiA:
undetectable
5ef0P-4efiA:
undetectable		 5ef0O-4efiA:
11.27
5ef0P-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5ef1O-4efiA:
undetectable
5ef1P-4efiA:
undetectable		 5ef1O-4efiA:
11.27
5ef1P-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5ef2O-4efiA:
undetectable
5ef2P-4efiA:
undetectable		 5ef2O-4efiA:
11.27
5ef2P-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  21
THR A 315
ILE A 352
SER A  24
ALA A  76
 None
 1.14A 5ef3O-4efiA:
undetectable
5ef3P-4efiA:
undetectable		 5ef3O-4efiA:
11.27
5ef3P-4efiA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 133
GLY A 335
SER A 339
GLY A 158
LEU A 234
 None
 0.83A 5gwxA-4efiA:
undetectable		 5gwxA-4efiA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		4 / 6 VAL A 336
MET A 164
ILE A 161
ASP A 159
 UNL  A 401 ( 4.9A)
None
None
None
 1.18A 5iwuA-4efiA:
undetectable		 5iwuA-4efiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 GLU A  11
LEU A 290
ALA A 344
PRO A 135
GLY A 333
 None
 1.14A 5syeB-4efiA:
undetectable		 5syeB-4efiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 116
LEU A  72
GLY A  70
ASN A 102
ALA A  76
 None
 1.19A 6r2eE-4efiA:
undetectable		 6r2eE-4efiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE
(Paraburkholderia
xenovorans) 		5 / 11 LEU A 116
LEU A  72
GLY A  70
ASN A 102
ALA A  76
 None
 1.20A 6r2eF-4efiA:
undetectable		 6r2eF-4efiA:
20.41