SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4efz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
 0.84A 1dmaB-4efzA:
undetectable		 1dmaB-4efzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 TYR A  16
GLY A   5
LEU A  50
ILE A 221
HIS A 212
 None
 1.22A 2a58A-4efzA:
undetectable
2a58E-4efzA:
undetectable		 2a58A-4efzA:
21.38
2a58E-4efzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ILE A 221
HIS A 212
TYR A  16
GLY A   5
LEU A  50
 None
 1.20A 2a58B-4efzA:
undetectable
2a58C-4efzA:
undetectable		 2a58B-4efzA:
21.38
2a58C-4efzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ILE A 221
HIS A 212
TYR A  16
GLY A   5
LEU A  50
 None
 1.21A 2a58C-4efzA:
undetectable
2a58D-4efzA:
undetectable		 2a58C-4efzA:
21.38
2a58D-4efzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 ASP A 183
HIS A  68
HIS A 143
ASP A  72
 None
CA  A 301 (-3.5A)
CA  A 301 (-3.6A)
CA  A 301 ( 4.9A)
 0.85A 3c0zC-4efzA:
undetectable		 3c0zC-4efzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 HIS A  73
THR A  11
ASP A  30
THR A  67
ASP A 170
 None
None
None
None
CA  A 301 (-3.3A)
 1.49A 3n58D-4efzA:
undetectable		 3n58D-4efzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 5 HIS A 212
SER A  15
ASP A  34
THR A  11
 None
 1.29A 3okxB-4efzA:
undetectable		 3okxB-4efzA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 5 CYH A 182
PRO A 141
THR A 171
THR A 251
 None
 1.48A 3q07A-4efzA:
undetectable		 3q07A-4efzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ASP A  72
ILE A  29
ASP A  30
ASP A 170
PHE A 173
 CA  A 301 ( 4.9A)
None
None
CA  A 301 (-3.3A)
None
 1.40A 3topA-4efzA:
undetectable		 3topA-4efzA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
 0.86A 3u9hA-4efzA:
undetectable		 3u9hA-4efzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
 0.87A 3u9hB-4efzA:
undetectable		 3u9hB-4efzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 ARG A 232
GLU A 230
THR A 226
 None
 0.92A 3v4tA-4efzA:
undetectable		 3v4tA-4efzA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
 0.87A 4bjcA-4efzA:
undetectable		 4bjcA-4efzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 HIS A 143
GLY A 169
HIS A  70
ASP A  72
HIS A  73
 CA  A 301 (-3.6A)
None
None
CA  A 301 ( 4.9A)
None
 1.30A 4bz6C-4efzA:
undetectable		 4bz6C-4efzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 4 PRO A 175
LEU A 172
ILE A 237
ARG A 197
 None
 1.44A 4f4dA-4efzA:
undetectable		 4f4dA-4efzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 7 ASP A  72
THR A  11
SER A 266
HIS A  73
 CA  A 301 ( 4.9A)
None
None
None
 1.30A 4o4dA-4efzA:
undetectable		 4o4dA-4efzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 GLY A 142
THR A 144
SER A 195
HIS A 139
 None
None
None
EDO  A 303 (-4.1A)
 1.05A 5ewuB-4efzA:
undetectable		 5ewuB-4efzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 6 ASP A 170
HIS A 143
HIS A  68
HIS A 212
HIS A  73
 CA  A 301 (-3.3A)
CA  A 301 (-3.6A)
CA  A 301 (-3.5A)
None
None
 1.24A 5ncdA-4efzA:
undetectable
5ncdD-4efzA:
undetectable		 5ncdA-4efzA:
21.52
5ncdD-4efzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 6 HIS A  73
ASP A 170
HIS A 143
HIS A  68
HIS A 212
 None
CA  A 301 (-3.3A)
CA  A 301 (-3.6A)
CA  A 301 (-3.5A)
None
 1.23A 5ncdB-4efzA:
undetectable
5ncdC-4efzA:
undetectable		 5ncdB-4efzA:
21.52
5ncdC-4efzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 6 ASP A 170
HIS A 143
HIS A  68
HIS A 212
HIS A  73
 CA  A 301 (-3.3A)
CA  A 301 (-3.6A)
CA  A 301 (-3.5A)
None
None
 1.30A 5nelA-4efzA:
undetectable
5nelD-4efzA:
undetectable		 5nelA-4efzA:
21.52
5nelD-4efzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 HIS A 143
HIS A  68
HIS A  70
 CA  A 301 (-3.6A)
CA  A 301 (-3.5A)
None
 1.01A 5oexA-4efzA:
undetectable		 5oexA-4efzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 LEU A  64
GLY A 274
ALA A 273
LEU A 121
ILE A  88
 None
 1.06A 6dh6B-4efzA:
undetectable		 6dh6B-4efzA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 HIS A  73
THR A  11
ASP A  30
THR A  67
ASP A 170
 None
None
None
None
CA  A 301 (-3.3A)
 1.49A 6f3nB-4efzA:
undetectable		 6f3nB-4efzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 ARG A 250
PHE A 184
PHE A 173
 None
 1.05A 6nknC-4efzA:
undetectable
6nknJ-4efzA:
undetectable		 6nknC-4efzA:
19.75
6nknJ-4efzA:
12.72