SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		4 / 8 PHE A 135
ILE A 108
LEU A 176
LEU A 145
 None
 0.67A 1eupA-4eg2A:
undetectable		 1eupA-4eg2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		3 / 3 SER A 164
GLU A 138
ASP A 173
 None
 0.86A 2avdB-4eg2A:
undetectable		 2avdB-4eg2A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		4 / 5 PRO A 239
SER A 237
LEU A 263
SER A 212
 None
 1.15A 3ijxH-4eg2A:
undetectable		 3ijxH-4eg2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ALA A 111
LEU A 139
VAL A 119
LEU A 157
ILE A 122
 None
 1.17A 3jw3A-4eg2A:
undetectable		 3jw3A-4eg2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		5 / 11 ARG A   4
GLY A 252
ALA A 103
GLY A  74
GLU A 104
 None
None
URI  A 302 (-3.8A)
None
URI  A 302 (-3.0A)
 1.17A 4a6nA-4eg2A:
undetectable		 4a6nA-4eg2A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		4 / 7 THR A  32
TYR A  63
GLY A 252
TYR A 224
 None
 0.99A 5hwaA-4eg2A:
undetectable		 5hwaA-4eg2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		4 / 8 GLN A 134
ALA A 142
SER A 174
HIS A 204
 None
 1.13A 5km8A-4eg2A:
undetectable
5km8B-4eg2A:
undetectable		 5km8A-4eg2A:
17.80
5km8B-4eg2A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		3 / 3 CYH A 106
MET A  90
ASN A  89
 None
None
URI  A 302 (-4.0A)
 1.16A 5qh8A-4eg2A:
undetectable		 5qh8A-4eg2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		5 / 9 ILE A 122
GLY A  74
ASN A 125
TYR A  63
ALA A  31
 None
 1.36A 5x66C-4eg2A:
undetectable		 5x66C-4eg2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		5 / 10 ILE A 122
GLY A  74
ASN A 125
TYR A  63
ALA A  31
 None
 1.38A 5x66D-4eg2A:
undetectable		 5x66D-4eg2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		4 / 7 VAL A  77
PRO A 240
LEU A 241
PHE A 135
 None
 1.13A 6aycA-4eg2A:
undetectable		 6aycA-4eg2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4eg2 CYTIDINE DEAMINASE
(Vibrio
cholerae) 		3 / 3 ILE A 124
THR A 123
PRO A 128
 None
None
URI  A 302 (-4.7A)
 0.60A 6ncsA-4eg2A:
undetectable		 6ncsA-4eg2A:
22.36