SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLU A 130
GLU A 131
LEU A 135
MET A 224
LEU A 115
 None
 1.49A 1a29A-4egcA:
undetectable		 1a29A-4egcA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.94A 1e06A-4egcA:
undetectable		 1e06A-4egcA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A 405
LEU A 404
LYS A 423
 None
 1.37A 1yajK-4egcA:
undetectable		 1yajK-4egcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.18A 2f16H-4egcA:
undetectable
2f16I-4egcA:
undetectable		 2f16H-4egcA:
19.01
2f16I-4egcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.17A 2f16V-4egcA:
undetectable
2f16W-4egcA:
undetectable		 2f16V-4egcA:
19.01
2f16W-4egcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 0.99A 2h42C-4egcA:
undetectable		 2h42C-4egcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 120
ASN A 118
THR A 245
 None
 0.70A 2pymB-4egcA:
undetectable		 2pymB-4egcA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A 601 (-2.9A)
 1.02A 2zw9A-4egcA:
undetectable		 2zw9A-4egcA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
 None
 1.22A 3a35B-4egcA:
undetectable		 3a35B-4egcA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.86A 3b6hA-4egcA:
undetectable		 3b6hA-4egcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.90A 3b6hB-4egcA:
undetectable		 3b6hB-4egcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.98A 3bgdA-4egcA:
undetectable		 3bgdA-4egcA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 8 PHE A 258
GLY A 327
LEU A 247
PRO A 159
 None
 1.11A 3bgdB-4egcA:
undetectable		 3bgdB-4egcA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.77A 3bjwC-4egcA:
2.0		 3bjwC-4egcA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.02A 3hs6A-4egcA:
undetectable		 3hs6A-4egcA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
TRP A 230
 MAL  A 601 (-2.9A)
MAL  A 601 (-2.7A)
None
None
MAL  A 601 (-3.2A)
MAL  A 601 (-2.9A)
MAL  A 601 (-3.8A)
MAL  A 601 (-2.9A)
MAL  A 601 (-4.5A)
 0.78A 3jyrA-4egcA:
55.6		 3jyrA-4egcA:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
GLU A 111
PRO A 154
TRP A 230
 MAL  A 601 (-2.9A)
MAL  A 601 (-2.7A)
None
None
MAL  A 601 (-3.2A)
MAL  A 601 (-2.9A)
MAL  A 601 (-2.9A)
MAL  A 601 (-3.5A)
MAL  A 601 (-4.5A)
 0.55A 3jyrA-4egcA:
55.6		 3jyrA-4egcA:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MAL  A 601 (-4.6A)
MAL  A 601 (-4.3A)
MAL  A 601 (-3.8A)
MAL  A 601 (-3.9A)
MAL  A 601 ( 4.4A)
MAL  A 601 (-3.7A)
 0.21A 3jyrA-4egcA:
55.6		 3jyrA-4egcA:
63.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A  49
ALA A 269
GLY A  54
THR A  53
ALA A  52
 None
 1.27A 3mg0H-4egcA:
undetectable
3mg0I-4egcA:
undetectable		 3mg0H-4egcA:
19.01
3mg0I-4egcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-4egcA:
undetectable		 3n8yB-4egcA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-2.9A)
None
 0.84A 3tbgB-4egcA:
undetectable		 3tbgB-4egcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-2.9A)
None
 0.83A 3tbgD-4egcA:
undetectable		 3tbgD-4egcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.37A 3vwqA-4egcA:
undetectable		 3vwqA-4egcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.39A 3vywD-4egcA:
undetectable		 3vywD-4egcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 601 (-2.9A)
 0.95A 4n48A-4egcA:
undetectable		 4n48A-4egcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.14A 4or0B-4egcA:
undetectable		 4or0B-4egcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.42A 6bm5A-4egcA:
undetectable		 6bm5A-4egcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 1.03A 6ecxA-4egcA:
undetectable		 6ecxA-4egcA:
19.57