SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ege'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 9 GLY A 206
GLU A 179
TYR A 339
ILE A 202
HIS A 214
 None
None
None
None
UNX  A 424 ( 3.2A)
 1.24A 1acjA-4egeA:
undetectable		 1acjA-4egeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 4 ILE A 202
LEU A 173
VAL A 182
ILE A 186
 None
 0.92A 1fm6D-4egeA:
undetectable		 1fm6D-4egeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 11 LEU A  75
ALA A 101
ALA A 103
VAL A  85
LEU A  55
 None
 1.25A 1hbpA-4egeA:
undetectable		 1hbpA-4egeA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 8 GLY A 206
GLU A 179
TYR A 339
HIS A 214
 None
None
None
UNX  A 424 ( 3.2A)
 1.10A 1maaD-4egeA:
undetectable		 1maaD-4egeA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 5 LEU A 123
LEU A 122
LEU A 129
LEU A 132
 None
 1.00A 2ab2B-4egeA:
undetectable		 2ab2B-4egeA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 6 ALA A 150
ASP A 153
GLU A 151
ARG A  14
 None
 1.41A 2ouzA-4egeA:
undetectable		 2ouzA-4egeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 12 PHE A 200
ILE A 351
HIS A 306
HIS A 313
ASP A 230
 None
None
ZN  A 411 (-3.3A)
UNX  A 421 ( 4.9A)
ZN  A 412 (-2.1A)
 1.39A 2pgfA-4egeA:
undetectable		 2pgfA-4egeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 12 LEU A  41
LEU A  55
GLN A 142
LEU A 104
VAL A 100
 None
 1.38A 2qd4B-4egeA:
undetectable		 2qd4B-4egeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 12 ILE A 351
ALA A 199
VAL A 198
THR A 244
ASP A 230
 None
None
None
ZN  A 412 (-4.8A)
ZN  A 412 (-2.1A)
 1.41A 2qo4A-4egeA:
undetectable		 2qo4A-4egeA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 10 ILE A 318
LEU A 140
THR A 137
ILE A 334
GLY A 309
 None
 1.28A 2v0mA-4egeA:
undetectable		 2v0mA-4egeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 10 ALA A  79
LEU A  15
ILE A  32
LEU A 140
THR A   8
 None
 1.10A 3jw3A-4egeA:
undetectable		 3jw3A-4egeA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 10 ILE A  65
THR A  53
TRP A  90
VAL A  85
SER A  74
 None
 1.45A 3kpbD-4egeA:
undetectable		 3kpbD-4egeA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 12 TYR A 235
GLY A 232
ALA A 199
SER A 196
ASP A 242
 None
None
None
None
ZN  A 412 ( 2.3A)
 1.10A 3nmuA-4egeA:
undetectable
3nmuF-4egeA:
undetectable		 3nmuA-4egeA:
22.62
3nmuF-4egeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 10 ALA A 187
ILE A 231
VAL A 165
VAL A 203
VAL A 201
 None
 1.06A 4j5jB-4egeA:
undetectable		 4j5jB-4egeA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		3 / 3 HIS A 166
GLY A 232
ILE A 162
 None
 0.62A 4k50A-4egeA:
undetectable		 4k50A-4egeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		3 / 3 HIS A 166
GLY A 232
ILE A 162
 None
 0.63A 4k50I-4egeA:
undetectable		 4k50I-4egeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		3 / 3 GLY A 337
GLU A 335
THR A 304
 None
UNX  A 420 (-2.0A)
None
 0.56A 4kouA-4egeA:
undetectable		 4kouA-4egeA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 9 ALA A  18
LEU A  27
GLY A  29
LEU A  30
LEU A 140
 None
 1.18A 5dqfA-4egeA:
undetectable		 5dqfA-4egeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 4 VAL A 274
ALA A 270
ILE A 318
THR A 304
 None
 1.13A 5e4dB-4egeA:
undetectable		 5e4dB-4egeA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 12 GLY A 194
ILE A 334
GLY A 305
GLY A 307
LEU A 155
 None
 0.85A 5eqbA-4egeA:
undetectable		 5eqbA-4egeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 8 ILE A 186
ALA A 189
ILE A 190
GLU A 193
 None
 0.57A 5mvmA-4egeA:
undetectable
5mvmB-4egeA:
undetectable		 5mvmA-4egeA:
12.23
5mvmB-4egeA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		4 / 7 ASP A 242
GLY A 305
GLY A 307
HIS A 313
 ZN  A 412 ( 2.3A)
None
None
UNX  A 421 ( 4.9A)
 1.02A 5n9xA-4egeA:
undetectable		 5n9xA-4egeA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		3 / 3 GLN A 142
ILE A 308
HIS A 306
 None
None
ZN  A 411 (-3.3A)
 0.69A 5z12B-4egeA:
undetectable		 5z12B-4egeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		5 / 9 VAL A 169
GLY A 250
VAL A 371
GLY A 224
PRO A 252
 None
 1.27A 5zniA-4egeA:
undetectable		 5zniA-4egeA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4ege DIPEPTIDASE PEPE
(Mycobacterium
ulcerans) 		3 / 3 TRP A  90
GLU A  71
GLU A  50
 None
ZN  A 417 (-2.3A)
ZN  A 414 (-2.2A)
 0.81A 6fhwA-4egeA:
undetectable		 6fhwA-4egeA:
13.66