SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A  87
VAL A  44
LEU A  45
SER A  46
 None
 1.23A 4e1gA-4egfA:
undetectable		 4e1gA-4egfA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ALA A  35
ALA A  39
ALA A  37
THR A  66
VAL A  68
LEU A  45
 None
 1.09A 4j6dA-4egfA:
undetectable		 4j6dA-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  35
ALA A  39
THR A  66
VAL A  68
LEU A  45
 None
 1.04A 4j6dB-4egfA:
undetectable		 4j6dB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  35
ALA A  39
ALA A  37
THR A  66
VAL A  68
 None
 1.09A 4jbtA-4egfA:
undetectable		 4jbtA-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  35
ALA A  39
ALA A  37
VAL A  68
LEU A  45
 None
 1.06A 4jbtA-4egfA:
undetectable		 4jbtA-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A  35
ALA A  39
ALA A  37
THR A  66
VAL A  68
 None
 1.09A 4jbtB-4egfA:
undetectable		 4jbtB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A  35
ALA A  39
ALA A  37
VAL A  68
LEU A  45
 None
 1.06A 4jbtB-4egfA:
undetectable		 4jbtB-4egfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 185
SER A 134
LEU A  98
ASN A 100
 None
 1.30A 4n09C-4egfA:
6.7		 4n09C-4egfA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  43
VAL A 237
ILE A  32
GLY A  29
LEU A  60
 None
 1.03A 4y8wC-4egfA:
undetectable		 4y8wC-4egfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 189
HIS A 188
VAL A 141
ILE A 150
VAL A  97
 None
 1.00A 5n0sA-4egfA:
2.4		 5n0sA-4egfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 189
HIS A 188
VAL A 141
ILE A 150
VAL A  97
 None
 0.99A 5n0tA-4egfA:
undetectable		 5n0tA-4egfA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 189
HIS A 188
VAL A 141
ILE A 150
VAL A  97
 None
 0.99A 5n0wB-4egfA:
undetectable		 5n0wB-4egfA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 189
HIS A 188
VAL A 141
ILE A 150
VAL A  97
 None
 0.99A 5n4iA-4egfA:
2.4		 5n4iA-4egfA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4egf L-XYLULOSE REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A  85
ASP A  96
VAL A 152
ILE A 150
ILE A  32
 None
 1.17A 5y80A-4egfA:
undetectable		 5y80A-4egfA:
15.09