SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
5 / 12 LEU A 265
LEU A 234
TYR A 193
ALA A 246
ALA A 249
None
1.06A 2bm9A-4egjA:
2.4
2bm9A-4egjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
4 / 8 TYR A  73
GLN A  80
ILE A  79
SER A  20
None
1.07A 2xytH-4egjA:
undetectable
2xytH-4egjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
4 / 7 TYR A  73
GLN A  80
ILE A  79
SER A  20
None
1.08A 2xytI-4egjA:
undetectable
2xytI-4egjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
4 / 5 GLY A 269
PRO A 271
ASN A 270
TYR A 272
None
1.17A 3u8qA-4egjA:
undetectable
3u8qA-4egjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
5 / 12 CYH A 196
LEU A 287
LEU A 203
ALA A 291
ALA A 198
None
1.19A 4x1kA-4egjA:
undetectable
4x1kB-4egjA:
undetectable
4x1kA-4egjA:
22.68
4x1kB-4egjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
5 / 12 ILE A 197
ALA A 195
ALA A 291
LEU A 203
PHE A 250
None
1.28A 4zo1X-4egjA:
undetectable
4zo1X-4egjA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
4 / 6 ARG A 260
GLY A 281
SER A 286
LEU A 287
None
0.40A 5bphA-4egjA:
37.0
5bphA-4egjA:
49.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans)
4 / 6 ALA A  13
SER A  26
ASP A  48
PRO A  49
None
1.20A 5c6pA-4egjA:
undetectable
5c6pA-4egjA:
23.89