SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  83
LEU A 135
ALA A  17
PHE A  21
GLY A  19
 LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
 1.14A 1cmaA-4egsA:
undetectable
1cmaB-4egsA:
undetectable		 1cmaA-4egsA:
21.20
1cmaB-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 10 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.11A 1cmcA-4egsA:
undetectable
1cmcB-4egsA:
undetectable		 1cmcA-4egsA:
21.20
1cmcB-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A  83
LEU A 135
ALA A  17
PHE A  21
GLY A  19
 LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
 1.15A 1cmcA-4egsA:
undetectable
1cmcB-4egsA:
undetectable		 1cmcA-4egsA:
21.20
1cmcB-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.15A 1mj2A-4egsA:
undetectable
1mj2B-4egsA:
undetectable		 1mj2A-4egsA:
21.20
1mj2B-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.10A 1mj2C-4egsA:
undetectable
1mj2D-4egsA:
undetectable		 1mj2C-4egsA:
21.20
1mj2D-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.10A 1mjoC-4egsA:
undetectable
1mjoD-4egsA:
undetectable		 1mjoC-4egsA:
21.20
1mjoD-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  83
LEU A 135
ALA A  17
PHE A  21
GLY A  19
 LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
 1.06A 1mjqA-4egsA:
undetectable
1mjqB-4egsA:
undetectable		 1mjqA-4egsA:
21.20
1mjqB-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 10 LEU A  83
LEU A 135
ALA A  17
PHE A  21
GLY A  19
 LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
 1.10A 1mjqC-4egsA:
undetectable
1mjqD-4egsA:
undetectable		 1mjqC-4egsA:
21.20
1mjqD-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.12A 1mjqC-4egsA:
undetectable
1mjqD-4egsA:
undetectable		 1mjqC-4egsA:
21.20
1mjqD-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 11 LEU A  83
LEU A 135
ALA A  17
PHE A  21
GLY A  19
 LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
 1.11A 1mjqI-4egsA:
undetectable
1mjqJ-4egsA:
undetectable		 1mjqI-4egsA:
21.20
1mjqJ-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A  17
PHE A  21
GLY A  19
LEU A  83
LEU A 135
 ALA  A  17 ( 0.0A)
PHE  A  21 ( 1.3A)
GLY  A  19 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 135 ( 0.6A)
 1.12A 1mjqI-4egsA:
undetectable
1mjqJ-4egsA:
undetectable		 1mjqI-4egsA:
21.20
1mjqJ-4egsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 8 GLY A  19
GLU A  18
ALA A  17
ILE A 139
 GLY  A  19 ( 0.0A)
GLU  A  18 ( 0.6A)
ALA  A  17 ( 0.0A)
ILE  A 139 ( 0.5A)
 0.75A 2dtjA-4egsA:
undetectable
2dtjB-4egsA:
undetectable		 2dtjA-4egsA:
23.21
2dtjB-4egsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A 119
GLY A   9
TYR A 121
 ASP  A 119 (-0.6A)
GLY  A   9 (-0.0A)
TYR  A 121 ( 1.3A)
 0.74A 3w9tC-4egsA:
undetectable		 3w9tC-4egsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		3 / 3 ASP A 119
GLY A   9
TYR A 121
 ASP  A 119 (-0.6A)
GLY  A   9 (-0.0A)
TYR  A 121 ( 1.3A)
 0.74A 3w9tG-4egsA:
undetectable		 3w9tG-4egsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 11 THR A 131
ALA A 132
LEU A  55
VAL A   3
ILE A 107
 THR  A 131 ( 0.8A)
ALA  A 132 ( 0.0A)
LEU  A  55 ( 0.6A)
VAL  A   3 ( 0.6A)
ILE  A 107 ( 0.4A)
 1.21A 4claA-4egsA:
undetectable		 4claA-4egsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 7 LEU A 125
VAL A 127
GLU A  53
TYR A  59
 LEU  A 125 ( 0.6A)
VAL  A 127 ( 0.6A)
GLU  A  53 ( 0.6A)
TYR  A  59 ( 1.3A)
 1.06A 4lb2A-4egsA:
undetectable		 4lb2A-4egsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 7 LEU A 125
VAL A 127
PRO A 120
GLU A  53
 LEU  A 125 ( 0.6A)
VAL  A 127 ( 0.6A)
PRO  A 120 ( 1.1A)
GLU  A  53 ( 0.6A)
 1.03A 4lb2A-4egsA:
undetectable		 4lb2A-4egsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A  63
ILE A  61
ASN A  22
ALA A  23
 ILE  A  63 ( 0.7A)
ILE  A  61 ( 0.4A)
ASN  A  22 ( 0.6A)
ALA  A  23 ( 0.0A)
 0.96A 4ou1A-4egsA:
undetectable		 4ou1A-4egsA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 SER A  36
VAL A  52
LEU A  55
ILE A  63
GLY A  19
 SER  A  36 ( 0.0A)
VAL  A  52 ( 0.6A)
LEU  A  55 ( 0.6A)
ILE  A  63 ( 0.7A)
GLY  A  19 ( 0.0A)
 0.98A 4y8wA-4egsA:
undetectable		 4y8wA-4egsA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 12 SER A  36
VAL A  52
LEU A  55
ILE A  63
GLY A  19
 SER  A  36 ( 0.0A)
VAL  A  52 ( 0.6A)
LEU  A  55 ( 0.6A)
ILE  A  63 ( 0.7A)
GLY  A  19 ( 0.0A)
 1.02A 4y8wB-4egsA:
undetectable		 4y8wB-4egsA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		6 / 12 GLY A  60
VAL A  54
ALA A 132
THR A 131
ALA A  17
GLY A 122
 GLY  A  60 ( 0.0A)
VAL  A  54 ( 0.6A)
ALA  A 132 ( 0.0A)
THR  A 131 ( 0.8A)
ALA  A  17 ( 0.0A)
GLY  A 122 ( 0.0A)
 1.43A 5hesA-4egsA:
undetectable		 5hesA-4egsA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		4 / 8 SER A  36
ALA A  17
ALA A  51
LEU A  55
 SER  A  36 ( 0.0A)
ALA  A  17 ( 0.0A)
ALA  A  51 ( 0.0A)
LEU  A  55 ( 0.6A)
 0.69A 5te8B-4egsA:
undetectable		 5te8B-4egsA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB
(Caldanaerobacter
subterraneus) 		5 / 10 VAL A   3
ALA A  34
LEU A  83
LEU A 138
LEU A 142
 VAL  A   3 ( 0.6A)
ALA  A  34 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 138 ( 0.6A)
LEU  A 142 ( 0.5A)
 1.01A 6f6nA-4egsA:
undetectable
6f6nB-4egsA:
undetectable		 6f6nA-4egsA:
15.56
6f6nB-4egsA:
19.51