SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		4 / 8 VAL A  69
TYR A  22
ASP A  24
ASP A  25
 None
 1.13A 1pk2A-4eguA:
undetectable		 1pk2A-4eguA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		4 / 6 VAL A  43
ASP A  24
LYS A  72
HIS A  65
 None
 1.23A 2zs9A-4eguA:
undetectable		 2zs9A-4eguA:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.37A 3o1cA-4eguA:
19.1		 3o1cA-4eguA:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.37A 3o1xA-4eguA:
19.1		 3o1xA-4eguA:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.36A 3qgzA-4eguA:
19.2		 3qgzA-4eguA:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		5 / 12 ILE A  70
ILE A  66
LEU A  28
VAL A  27
ILE A  62
 None
 0.93A 4azvA-4eguA:
2.5		 4azvA-4eguA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		4 / 5 LEU A 106
PHE A  79
ILE A  41
ILE A  73
 None
 1.01A 5dzk4-4eguA:
undetectable
5dzkg-4eguA:
undetectable
5dzkm-4eguA:
undetectable
5dzkn-4eguA:
undetectable		 5dzk4-4eguA:
6.06
5dzkg-4eguA:
19.25
5dzkm-4eguA:
18.81
5dzkn-4eguA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		4 / 8 ASN A  89
GLN A  96
HIS A 102
HIS A 104
 5GP  A 201 ( 3.9A)
K  A 203 (-4.1A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.41A 5km8A-4eguA:
15.6
5km8B-4eguA:
18.9		 5km8A-4eguA:
30.00
5km8B-4eguA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		8 / 12 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
VAL A  98
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 (-3.8A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.51A 5km9B-4eguA:
19.0		 5km9B-4eguA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		5 / 12 ASP A  32
ASN A  34
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-2.2A)
5GP  A 201 (-3.1A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.88A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 12 PHE A   8
ILE A  11
ASP A  32
LEU A  42
VAL A  98
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 (-3.8A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.34A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73