SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.28A 1g50C-4egvA:
undetectable		 1g50C-4egvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 206
LEU A 202
ASP A 199
LEU A 195
 None
 1.24A 1n13B-4egvA:
0.7
1n13C-4egvA:
0.0		 1n13B-4egvA:
10.70
1n13C-4egvA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 379
ALA A 376
HIS A 373
 None
 0.77A 1q23C-4egvA:
undetectable		 1q23C-4egvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 379
ALA A 376
HIS A 373
 None
 0.79A 1q23L-4egvA:
undetectable		 1q23L-4egvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 113
THR A 110
ALA A 109
VAL A 379
 None
 0.87A 2a1hA-4egvA:
undetectable
2a1hB-4egvA:
undetectable		 2a1hA-4egvA:
20.97
2a1hB-4egvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.23A 2j7xA-4egvA:
undetectable		 2j7xA-4egvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.20A 2yjaB-4egvA:
undetectable		 2yjaB-4egvA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A  16
LEU A 262
SER A 104
ILE A 375
GLY A 364
 None
 1.25A 3cv9A-4egvA:
undetectable		 3cv9A-4egvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 310
LEU A 391
ALA A 399
GLY A 343
LEU A 321
 None
 1.09A 3ln1D-4egvA:
undetectable		 3ln1D-4egvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ILE A   9
VAL A 379
ARG A 383
 None
 0.67A 3p73A-4egvA:
undetectable		 3p73A-4egvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  88
VAL A  84
TYR A  80
THR A  61
ILE A  55
 None
 1.27A 3vrjA-4egvA:
undetectable
3vrjC-4egvA:
undetectable		 3vrjA-4egvA:
20.81
3vrjC-4egvA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 484
TYR A 451
GLY A 486
PRO A 488
 None
 1.30A 4e3aA-4egvA:
undetectable		 4e3aA-4egvA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TYR A 169
HIS A 173
ARG A 172
 None
 0.98A 4e7bC-4egvA:
undetectable		 4e7bC-4egvA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 273
ALA A  52
ILE A  55
LYS A 272
 None
 1.29A 4eixA-4egvA:
undetectable		 4eixA-4egvA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.22A 4j26A-4egvA:
undetectable		 4j26A-4egvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 494
GLY A 442
LYS A 492
 None
 0.66A 4k50A-4egvA:
undetectable		 4k50A-4egvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 494
GLY A 442
LYS A 492
 None
 0.64A 4k50E-4egvA:
undetectable		 4k50E-4egvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 396
SER A 400
ALA A 399
GLU A 291
 None
 1.01A 4m93B-4egvA:
undetectable
4m93C-4egvA:
undetectable		 4m93B-4egvA:
15.89
4m93C-4egvA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ASP A 328
ALA A 260
GLY A 359
PHE A 363
SER A 371
 None
 1.34A 4mmeB-4egvA:
0.1		 4mmeB-4egvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR A 407
GLN A 106
SER A 371
ASP A 350
 None
 1.37A 4qtuB-4egvA:
undetectable		 4qtuB-4egvA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 262
LEU A 263
ILE A 116
GLY A 113
LEU A 283
 None
 1.17A 5dxbB-4egvA:
undetectable		 5dxbB-4egvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 203
LEU A 207
ALA A 205
PHE A 208
PRO A 247
 None
 1.13A 5k9dA-4egvA:
undetectable		 5k9dA-4egvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 PRO A 334
GLY A 183
SER A 331
LEU A 360
VAL A 251
 None
 0.94A 5o96A-4egvA:
undetectable
5o96B-4egvA:
undetectable		 5o96A-4egvA:
18.40
5o96B-4egvA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A 398
LEU A 175
HIS A 173
PHE A 335
 None
 0.99A 5vkqA-4egvA:
undetectable
5vkqB-4egvA:
undetectable		 5vkqA-4egvA:
15.79
5vkqB-4egvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 335
ILE A 398
LEU A 175
HIS A 173
 None
 0.99A 5vkqA-4egvA:
undetectable
5vkqD-4egvA:
undetectable		 5vkqA-4egvA:
15.79
5vkqD-4egvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 397
GLY A 301
ALA A 188
SER A 400
THR A 446
 None
 0.89A 5w4zA-4egvA:
undetectable		 5w4zA-4egvA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 397
GLY A 301
ALA A 188
SER A 400
THR A 446
 None
 0.93A 5w4zB-4egvA:
undetectable		 5w4zB-4egvA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 257
SER A 222
SER A 221
PHE A  15
LEU A 366
 None
 1.09A 6chgC-4egvA:
undetectable		 6chgC-4egvA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 407
LEU A 283
SER A 104
ILE A 375
LEU A 391
 None
 1.38A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 407
LEU A 283
SER A 104
ILE A 375
THR A  61
 None
 1.25A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4egv ACETYL-COA
ACETYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 260
GLY A 259
LEU A  32
GLY A  60
TYR A  80
 None
 1.25A 6nm4B-4egvA:
undetectable		 6nm4B-4egvA:
15.28