SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4egw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 143
PRO A  81
PHE A  83
ARG A 149
 None
 1.05A 1oniG-4egwA:
undetectable
1oniI-4egwA:
undetectable		 1oniG-4egwA:
19.86
1oniI-4egwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 104
ILE A 132
ILE A  48
LEU A 140
 None
 0.82A 1zgyA-4egwA:
undetectable		 1zgyA-4egwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 115
GLY A  93
ILE A  76
ALA A 111
ILE A 112
 None
 0.87A 3ekpB-4egwA:
undetectable		 3ekpB-4egwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 115
GLY A  93
ILE A  76
ALA A 111
ILE A 112
 None
 0.97A 3ekpC-4egwA:
undetectable		 3ekpC-4egwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  93
ILE A 208
PHE A 134
PHE A 128
 None
None
None
BU1  A 319 (-3.7A)
 0.90A 3ko0B-4egwA:
undetectable
3ko0J-4egwA:
undetectable		 3ko0B-4egwA:
15.00
3ko0J-4egwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  77
GLY A  58
ILE A  50
ILE A  57
LEU A 100
 None
 0.79A 3uj7B-4egwA:
undetectable		 3uj7B-4egwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 110
PRO A  81
ILE A 150
ARG A 114
 None
 1.33A 3v4tC-4egwA:
0.0
3v4tD-4egwA:
0.6		 3v4tC-4egwA:
23.47
3v4tD-4egwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  41
SER A 106
LEU A  18
LEU A 100
ILE A  50
 None
 1.18A 4dm8A-4egwA:
undetectable		 4dm8A-4egwA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  96
LEU A 101
ARG A 214
LEU A 140
 None
 0.94A 5b1aA-4egwA:
2.4
5b1aJ-4egwA:
undetectable		 5b1aA-4egwA:
18.58
5b1aJ-4egwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  96
LEU A 101
ARG A 214
LEU A 140
 None
 0.94A 5b3sA-4egwA:
undetectable
5b3sJ-4egwA:
undetectable		 5b3sA-4egwA:
18.58
5b3sJ-4egwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 180
LEU A 158
LEU A 161
ILE A 244
LEU A 165
 None
BU1  A 305 (-3.6A)
None
None
None
 1.11A 5toaB-4egwA:
undetectable		 5toaB-4egwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4egw MAGNESIUM TRANSPORT
PROTEIN CORA
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  96
LEU A 101
ARG A 214
LEU A 140
 None
 0.96A 5zcqA-4egwA:
2.3
5zcqJ-4egwA:
undetectable		 5zcqA-4egwA:
18.58
5zcqJ-4egwA:
11.31